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SignificanceWe propose to extend and customize inseRT MRI s Real Time MR image guided surgical platformoriginally developed for cerebral biopsy and direct injection cancer therapiesto overcome shortcomings in CT guidance of a promising new thrombolytic therapy for intracerebral hemorrhageICHICH is a devastating injury creating stroke like outcomes inpeople in the USA each yearDamage from mechanica ...

Project Summary/AbstractNeurological and psychiatric disorders, including drug abuse and addiction, exert a devastating personal and economic toll on patients, families, caregivers, and society. This is in part due to our failure in developing effective medications, which in turn is due to the use of drug discovery platforms that are often not relevant to target diseases. The recent development of ...

PROJECT SUMMARY ABSTRACT This SBIR proposal is aimed at demonstrating feasibility of developing a technically simple and highly accurate in vitro diagnosticIVDassay for Heparin induced thrombocytopeniaHITa serious complication of heparin treatmentThe proposed assay is based on recent findings that Platelet FactorPFtreated platelets can be used for the sensitive and specific detection of clinically ...

The proposed research will advance preclinical characterization and validation of a novel drug for asthmaA growing body of research has uncovered functional gamma amino butyric acid type A receptorGABAARsignaling in non neuronal cellsOur research has demonstrated that ligands activating GABAAR subtypes located on airway smooth muscle and immune cells reduce airway hyper responsivenessAHRand inflam ...

THE IMMOBILIZATION OF PROTEINS ON INSOLUBLE SURFACES IS IMPORTANT IN DIAGNOSTIC INSTRUMENTATION AND IN VIVO MONITOR-ING. IMPROVEMENTS IN THE SURFACE ANTIBODY INTERACTIONS SHOULD RESULT IN MORE EFFICIENT APPROACHES TO IMMUNO- DIAGNOSTICS. THIS WOULD BE ESPECIALLY USEFUL IN THE FIELD OF TUMOR MARKER DETECTION WHERE PANELS OF ANTIGENS MAY BE NEEDED FOR PROPER DIAGNOSIS. THIS RESEARCH IS THE DEVELOPME ...

PROJECT SUMMARYPersonal sound amplification productsPSAPshave recently become available to the publicPSAPs serve a potentially important role in providing audibility of sounds for adults who have difficulty hearing in some daily living situationsbut may not be candidates for traditionalhigh amplification hearing aidsFewer thanof adults with hearing loss reporting use of hearing aidsciting high cos ...

Project Summary Development of the High Throughput APT SNAP Platform for Rapid Identificationof Nuclease Resistant RNA Aptamers against pMissense MutationsPIsChristopher LWarren and Mary SOzers Normal proteins are often mutated in cancergenerating dominant negative effects as well as gain of function activity that contribute to cancer development and to the inhibition of therapeutic responsesProte ...

SUMMARY Cytoplasmic nucleic acids alert the immune system to invading pathogens and trigger a robust type I interferonIFNresponse via activation of the STINGstimulator of interferon genesreceptorThe sensor for cytoplasmic nucleic acids was recently discovered to be cyclic GMP AMP synthasean enzyme that produces a unique cyclic dinucleotide second messengercGAMPthat serves as an agonist for the STI ...

GENERATION OF MAGNETIC RESONANCE IMAGES OF INTRACRANIAL AND EXTRACRANIAL CAROTID ARTERIAL LUMENS, TOGETHER WITH RELATED VOLUME BLOOD FLOW INFORMATION FOR EACH LUMEN, HAS POTENTIAL FOR PROVIDING A NONINVASIVE AND MORE DEFINITIVE TECHNIQUE FOR DIAGNOSIS OF INCIPIENT STROKE DUE TO ARTERIAL DISEASE THAN EITHER ULTRASOUND OR ANGIOGRAPHY. TO DEMONSTRATE THIS POTENTIAL, WE PROPOSE TO APPLY A SENSITIVE LI ...

PROJECT SUMMARY Detrimental health impacts of lead are largely attributed to long-term exposures to undetected lead, which are particularly troublesome and problematic because of the neurological damage to children, a situation that should not be tolerated by an advanced society like the U.S. The Flint Water Crisis and many other water catastrophes could have been avoided if early warning can be m ...