Award Data

Project Summary Opioids like morphine and hydrocodone are generally the most effective therapeutics for treatment of moderate to severe pain. However, their use is limited by serious side effects - tolerance, constipation, respiratory depression, physical dependence and high addictive potential. The frequency of clinical pain, coupled with a lack of alternative therapeutic options has led to a nat ...

Dopamine receptors are a family of G protein-coupled receptors (GPCRs), and can be further divided into D1-like (D1 and D5) and D2-like (D2, D3 and D4) subfamilies. In this proposal, we focus on D1 receptor, which is widely expressed in brain at high levels. Modulation of D1 activity is implicated in the treatment of many psychiatric and neurological disorders, such as schizophrenia, attention def ...

PROJECT SUMMARY GoDx, Inc. has been developing a prototype multiplexed paper strip device for the detection of the DNA and RNA of gastrointestinal pathogens at the point-of-need in andlt; 30 minutes with funding from the NCATS SBIR parent grant TR 001912. We have used the same platform technology we are developing in the parent grant to develop a rapid (andlt;30 minute), low-cost and instrument-fr ...

The project team will develop the EdMod platform for special education practitioners to enter and track information specific to IEPs, such as diagnosis classification, goals, and data collection of those goals. The platform will then generate research-based strategies for teachers to support students with or at risk for disabilities during classroom instruction or in testing. The platform will pre ...

In this project, the team will develop a performance-based lab for the high school level. The Inq-ITS Performance Based Labs for High School Physics and Physical Science will integrate "using mathematics" practices with other science practices to study physics/physical science phenomena. An accompanying teacher dashboard will generate immediate, diagnostic, and actionable alerts driven by algorith ...

In this project, the team will create the technology-delivered version of Reading Roots II: Reading "Between the Lions," by integrating content from Between the Lions, including multimedia videos and learning games to personalize learning. To participate in the intervention, students will work for 10 to 30 minutes per day in pairs while sharing a laptop or tablet. Students will alternate in roles ...

History Maker VR is a playful virtual reality (VR) content-creation tool that allows students to embody historical characters in immersive settings, record performances featuring those characters, and share their performance files to demonstrate material mastery. History Maker VR is designed to scaffold creative storytelling, and to encourage embodied learning and for students to take pride in con ...

Graspable Math Activities is web application that middle and high school students use on laptops and tablets to practice algebra and receive instantaneous feedback. Activities are based on an algebra notation technology that can promote procedural fluency while allowing students to focus on strategy and the connection between concepts and procedures. The team will produce a website that will inclu ...

In previous R&D, the developers created codeSpark Academy, a game that employs a visual and block-based approach with puzzles to teach coding skills to students ages 5 to 9 years old. codeSpark Academy is in widespread use in and out of schools around the world. In this project, the developers will expand storytelling creative tools within the existing game. The pretend-play scenarios will include ...

In previous research and development, the developers created VidCode, a website where students in grades 4 to 12 manipulate digital media assets such as photos, audio, and graphics to create special effects in videos while learning about the code responsible for the action. VidCode is currently in widespread use in schools and districts around the country. In this project, the team will develop a ...