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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 1 - 10 of 4597 results
  1. Clinical Human Cell Production System for Broad Use

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): As a result of growing evidence of their therapeutic potential in cancer, infectious diseases, and tissue repair, there is an enormous increase in the research and discovery of cell-based medical treatments that require cultured cells. A large unmet need exists for a cost-effective system that will facilitate the development of clinical cell production capabil ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  2. Enhanced Tumor Antigen Priming of Dendritic Cell Vaccine

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by the applicant): Dendritic cells have been shown to initiate, regulate, and direct cytolytic T-cell-mediated immune responses against tumor antigens in human patients. Recent clincal trials have demonstrated induction of clinically significant immune responses against malignant diseases using DCs primed ex vivo with autologous tumor antigens including tumor cell lysates. E ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  3. Automated Perfused Culture Process for Adult Stem Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Adherent mesenchymal cell populations derived from bone marrow (BM) have the capability of differentiating into multiple cell lineages in vitro and in vivo. The potential use of these populations, referred to as marrow stromal cells (MSC), in clinical applications to treat nonhematopoietic disorders is being intensely investigated. Ex vivo expansion is being us ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  4. Clinical-scale Production of Osteoprogenitor Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Due to morbidity and limited amounts of material, alternatives to autologous grafts for bone repair are desirable. Mixtures of marrow stromal cells (MSC) and carrier matrices are known to augment bone repair. Increasing the number of MSC through ex vivo expansion may significantly increase the amount and rate of new bone formation. In this proposal, the abilit ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  5. Automated Large-Scale Production of Endothelial Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Treatment of ischemia by administration of bone marrow (BM)-derived endothelial progenitor cells (EPC) or ex vivo expanded EPC populations has been shown to enhance vascular regeneration in animal models and in clinical trials. For cell therapy to be practical in a clinical setting, simple, efficient, GMP compliant methods for cell production are needed. Aastro ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  6. EMERGENCY VENTILATORY SUPPORT DEVICES BASED ON H202

    SBC: Abel Company            Topic: N/A

    THERE IS A CLEAR NEED FOR AN EMERGENCY OXYGEN DELIVERY SYSTEM THAT COMBINES RELIABILITY, LONG-TERM STORAGE CAPABILITY, VARIABLE AND CONTROLLABLE FLOW RATE, SMALL SIZE,SAFETY, AND SIMPLICITY OF USE. OF THE AVAILABLE OXYGEN STORAGE MEDIA, CHEMICAL SYSTEMS OFFER A REASONABLE LIKELI- HOOD OF ACHIEVING SUCH A SYSTEM. THIS PROJECT WILL INVESTIGATE THE FEASIBILITY OF USING LOW-COST HYDROGEN PEROXIDE AS T ...

    SBIR Phase II 1987 Department of Health and Human Services
  7. OXYGEN GENERATOR FOR AMBULATORY COPD PATIENTS

    SBC: Abel Company            Topic: N/A

    THE SPECIFIC GOAL OF THIS RESEARCH IS THE DEVELOPMENT OF A PORTABLE OXYGEN SOURCE SUITABLE FOR USE IN PROVIDING SUPPLE-MENTAL OXYGEN TO INDIVIDUALS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) RESULTING FROM CHRONIC BRONCHIOLI- TIS, PULMONARY EMPHYSEMA, ASTHMA, OR CHRONIC BRONCHITIS. THE CONCEPT IS BASED ON THE USE OF A COMMON, LOW-COST, HOUSEHOLD CHEMICAL THAT GENERATES OXYGEN WHEN WATER PLU ...

    SBIR Phase II 1987 Department of Health and Human Services
  8. DEVELOPMENT AND TESTING OF LAMINAR FLOW ISOLATORS FOR RODENT COLONIES

    SBC: Abel Company            Topic: N/A

    THE SPECIFIC AIM OF THIS STUDY IS TO DESIGN AND EVALUATE THEUSE OF HEPA-FILTERED, LAMINAR FLOW ISOLATION SYSTEMS AS SUBSTITUTES FOR PRESENT BARRIER SYSTEMS IN GERM-FREE AND GNOTOBIOTIC RESEARCH USING RODENTS AND OTHER SMALL ANIMALS.

    SBIR Phase I 1987 Department of Health and Human Services
  9. A PERIODONTAL TEMPERATURE PROBE

    SBC: ABIOMED, INC.            Topic: N/A

    THE OBJECTIVE OF THIS PROPOSED EFFORT IS DIRECTED TOWARDS THE DEVELOPMENT OF A PERIODONTAL TEMPERATURE PROBE WITH RESPONSE TIME AND SENSITIVITY CHARACTERISTICS WHICH CAN POTENTIALLY PROVIDE AN OBJECTIVE AND SIMPLE DIAGNOSTIC TECHNIQUE IN ASSESSING PERIODONTAL DISEASE ACTIVITY. STUDIES HAVE SUGGESTED THAT INFLAMED SULCI ARE ACCOMPANIED BY ELEVATED TEMPERATURE INDICATIONS. CONVENTIONAL TECHNIQUES, S ...

    SBIR Phase II 1985 Department of Health and Human Services
  10. IN VIVO TOTAL BODY LEAD ANALYSIS BY X-RAY FLUORESCENCE

    SBC: ABIOMED, INC.            Topic: N/A

    THERE ARE AN ESTIMATED 600,000 CHILDREN UNDER SIX YEARS OLD WITH ELEVATED BLOOD LEAD LEVELS AND ONLY 5,000 PER YEAR UNDERGOING TREATMENT; AS YET, NO TECHNIQUE IS AVAILABLE TO MEASURE TOTAL BODY LEAD BURDEN. THIS PROPOSAL DESCRIBES A TECHNIQUE WHICH USES X-RAY FLUORESCENCE IN A TRANSMISSION GEOMETRY TO MEASURE THE TOTAL BODY-BURDEN OF LEAD, IN VIVO, NONINVASIVELY. A SYSTEM USING A GOLD CALIBRATION ...

    SBIR Phase II 1987 Department of Health and Human Services
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