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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Exosomal microRNA profiles as diagnostic biomarkers of ovarian cancer

    SBC: TEKSHIFA, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Detection of ovarian cancer at Stage I results in 5-year survivals of greater than 90%; however, only 23% of ovarian cancers are diagnosed early, with 67% being diagnosed with metastatic disease. Thus, new markers are being sought to accurate identify patients with ovarian cancer, particularly in early stage. Emerging evidence suggests the potential involvement ...

    STTR Phase I 2009 Department of Health and Human Services
  2. Delivery of Polyphenols in Gum for Treatment of Gingivitis

    SBC: FOUR TIGERS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Periodontitis represents a polymicrobial disease, in which a complex microbial ecology that matures in biofilms in the subgingival sulcus triggers a chronic immunoinflammatory lesion that destroys soft and hard tissues of the periodontium. The ability to identify therapeutics, to enable more effective control and/or prevention of gingival inflammation, is a cr ...

    STTR Phase I 2009 Department of Health and Human Services
  3. Ultra-soft atomic force microscope (USAFM) technology using nano-cantilevers for

    SBC: NaugaNeedles LLC            Topic: N/A

    DESCRIPTION (provided by applicant): NaugaNeedles LLC in collaboration with researchers from Purdue University are proposing to develop an advanced new Ultra-Soft Atomic Force Microscope (USAFM). This USAFM can gently create images of soft biological samples in buffer solutions with sub-picoNewton (pN) forces and sub-nm lateral resolution. This new AFM technology will have a high-bandwidth to ensu ...

    STTR Phase I 2009 Department of Health and Human Services
  4. Natural Product Protease Inhibitors: Therapeutics for Virulence of Oral Pathogens

    SBC: ORACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Oral infections associated with the gingival margin and subgingival sulcus lead to host inflammatory responses. Gingivitis is primarily a response to the bacteria in plaque. This disease affects nearly everyone in the population, at some time during their life. Periodontitis is a multifactorial disease that encompasses the hard and soft tissue, microbial col ...

    STTR Phase I 2009 Department of Health and Human Services
  5. Novel, Optimal, Physics-Based Reduced Order Models for Nonlinear Aeroelasticity

    SBC: Advanced Dynamics, Inc.            Topic: AF08BT03

    Research is proposed for the development and implementation of state of the art, reduced order nonlinear aeroelastic models for multidisciplinary/multi-fidelity optimization problems. Highly efficient and accurate aeroelastic simulation tools will be constructed based upon the mathematical formalism of optimal prediction theory and a novel implementation of a filtered harmonic balance solution met ...

    STTR Phase I 2009 Department of DefenseAir Force
  6. Multi-layered lightweight alloy development for improved blast and penetration resistance

    SBC: ATI, INC.            Topic: A09AT010

    This program is to develop multi-layered,light weight armor alloys systems that offer improved fragmentation and armor piercing performance as compared to any other monolithic structures. Such alloys and laminated configuration will be developed by utilizing advanced computational techniques to assist in the development of complimentary alloys that would provide an optimal combination of hardness ...

    STTR Phase I 2009 Department of DefenseDefense Advanced Research Projects Agency

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