Award Data

Increasingly defined vaccines against infectious diseases are better tolerated but less immunogenicrequiring use of an immunological adjuvant for best effectAdjuvance s semi synthetic saponin adjuvant TiterQuilTQLhas shown remarkable efficacy with a variety of antigens with no detectable reactogenicityWhen combined withof the leading vaccines against influenzaFluzoneFluarix and Flublokstriking aug ...

Over one million Americans andmillion people worldwide are infected with HIVmaking it one of the most pressing public health concerns of our timeUnfortunatelythere are no vaccines available and treatment requires lifelong anti retroviral therapiesThis proposal combines two technologies for the development of a vaccine against HIVEnva novel adjuvantspontaneous nanoliposome antigen particleizationSN ...

The project goal is to develop digital delivery of Community Reinforcement and Family TrainingCRAFTmethodologyan empirical family behavioral intervention to improve outcomes around treatment entryfamily functioning and substance use

The corneathe outermost window of our visual systemis vulnerable to various types of infections and diseasesCorneal disease is one of the leading causes of visual deficiency and blindness !There are nearlymillion bilaterally corneal blind persons worldwideand an estimatedmillion people affected by unilateral corneal blindness globallyIn a conservative estimatecorneal diseases affect nearlypeople i ...

PROJECT SUMMARY In the U.S. ~5 million individuals receive blood transfusions annually. Increasingly, these recipients are being put at risk of infection with Babesia microti, a tick-transmitted blood-borne parasite that resides in red blood cells (RBCs) and causes the disease babesiosis. B. microti represents a significant threat to the US blood supply as it survives blood banking procedures and ...

SUMMARY Natural products derived from plants have played crucial roles in the treatments of many diseases throughout historyHoweverscarce natural sources and complex chemical synthesis have limited research and development and increased costs on these productsAn example of this is the non psychoactive cannabinoids found in cannabis plantsThere are overlow abundant cannabinoids that are known to be ...

Preclinical positron emission tomographyPETplays a significant role in monitoring radiotracer biodistributions for the development of new therapiesThe standardized uptake valueSUVhas become one of the most important quantitation measures in PET analysisHoweverSUV extraction from PET data hinges on the ability to clearly delineate the organ region of interestROIfrom an anatomical referenceCross com ...

PROJECT SUMMARY Hantaviruses are an emerging family of highly pathogenic viruses that cause 100-200,000 cases of two severe febrile illnesses a year; Hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). While the annual incidence of infections are relatively low compared to other viral infections, some hantavirus strains are particularly deadly, causing a 35 ...

Abstract Roughlynew drugs and chemicals are commercialized each year successfully clearing research and developmentRandamp Dhurdles to meet the safety requirements of regulators such as the U SFood and Drug AdministrationThese successeshoweverare the exception rather than the rule making it advantageous for Randamp D programs to have methods in place that ensure unsafe compoundsfail fastwell befor ...

Abstract Mirna Analytics is proposing to develop a microRNAmiRNAmarker for pulmonary hypertensionThis proposal is focused on the identification of optimal miRNAandapos s to form composite markers that can be measured in the serum plasmaPulmonary hypertensionan excessive increase of the pressure in the pulmonary circulationcan be due to many different reasonsPulmonary hypertension can be a deadly d ...