Award Data

N/A

A multiscale computational tool to simulate the PK of orally administered drugs in the human GI tract Project Summary AbstractMost FDA approved drugs are administered orallydespite the complex process of oral drug absorption that is difficult to analyze experimentallyOral bioavailability is dependent on the interplay between multiple and simultaneous processes that are dependent on both the drug c ...

DESCRIPTION provided by applicant Early diagnosis of an infection in neutropenic cancer patients is critical for timely treatment But the diagnosis of an infection in these patients especially at an early stage can be very challenging Therefore there is a great need for sensitive biomarkers that can rapidly predict an infection and provide possible outcomes We have already reported that s ...

DESCRIPTION provided by applicant Lung cancer causes more deaths in men and women than any other cancer in the United States Late detection of disease and inability to effectively treat this malignancy with chemotherapy are the main reasons for low survival rates There is an urgent medical need to develop new molecularly targeted drugs for treating lung cancer although it has been challengin ...

PROJECT SUMMARYABSTRACT To datethe standard method to access a mouse tail vein is manual injectionbut its yield rate is poor in generalThis leads to multiple needle insertions associated with tissue damage and painBesidesfailure in tail vein injection leads to data lossand thereby more animals will be required to compensate itFinallythe dose variation induced by unreliable injection increases erro ...

PAProject Summary Abstract SERis a long acting polymer pro drug of buprenorphine that is being developed to treat postoperative pain following major surgeries such as bunionectomyabdominoplastythoracotomy and knee and hip surgerySERhas no biological activity by itselfbut when administered in vivo by subcutaneous injection it enters the vascular compartment where a plasma esterasebutyrylcholinester ...

PROJECT SUMMARY The for profit small business concernTricorder Array Technologies LLCwill developin partnership with the University of Alabama at BirminghamSIDECAReSensing and Integrating Data for Environmental Conditions in Animal ResearchThis device will automate collection of relevant data that will enhance consistency in animal models used to study human health treatment researchOur innovative ...

DESCRIPTION provided by applicant More than of the population has unruptured cerebral aneurysms approximately million people in the US About rupture per year with devastating consequences More than of patients with ruptured aneurysms die and of who survive have significant disabilities Detachable microcoils are now used in more than of treated aneurysms The risk ...

Protecting the effectiveness of US advanced weapon systems and the technology they rely on is a national priority. Unfortunately, individuals tasked with this mission are met with disjointed guidance, no training, and competing processes to consider. It is no wonder adversaries continue to exploit these weaknesses in the Department of Defense (DOD); stealing our Critical Program Information (CPI) ...

DESCRIPTION provided by applicant In this Phase I project Blondin Bioscience LLC a start up company in Birmingham AL proposes to develop a rapid accurate and precise fluorometric assay for quantifying cell free telomeric DNA fragments cf tDNA within serum in order to monitor the effectiveness of chemotherapy treatments In our preliminary work conducted at the University of Alabama at ...