Award Data

PAProject Summary Abstract SERis a long acting polymer pro drug of buprenorphine that is being developed to treat postoperative pain following major surgeries such as bunionectomyabdominoplastythoracotomy and knee and hip surgerySERhas no biological activity by itselfbut when administered in vivo by subcutaneous injection it enters the vascular compartment where a plasma esterasebutyrylcholinester ...

PROJECT SUMMARY The prevalence of Alzheimer’s Disease (AD) and other dementias is steadily climbing and predicted to affect as many as 16 million Americans by 2050. In 2016, 59% of dementia caregivers reported experiencing high levels of emotional and physical stress, and the risk that the chronic stress of dementia caregiving places on caregivers for developing a range of physical and mental he ...

Project SummaryThere is an enormous need for the development of a new class of neurotransmitterNTsensors that are versatileselectivesensitive and reliable to allow investigation of the neurobiological mechanisms of behavior and disease symptomsThis STTR proposal will focus on implementing a novel microarray probe for in vivoreal time sensing of glutamateGLUand gamma aminobutyric acidGABAGLU and GA ...

PROJECT SUMMARY Significance: Americaandapos;s health care system remains challenged by tens of billions of dollars of fraud and inefficiencies. Lost and stolen equipment cost about $4,000 per hospital bed, increasing to $8,000 when expenses incurred from out-of-place equipment are added. In addition, a 2017 report estimates $95 billion was lost to fraud, waste, abuse, and other improper payments ...

Project Summary Abstract TITLEPERCUTANEOUS TREATMENT OF PERIPHERAL ARTERIAL OCCLUSIVE DISEASE WITH IMPLANTATION OF SERIALBALLOON EXPANDABLEPACLITAXEL ELUTING RESORBABLE SCAFFOLDSthe Efemoral DeviceAbstract Peripheral Arterial Occlusive DiseasePAODalso known as Peripheral Vascular Diseasepoor circulationorhardening of the arteriesis a worldwide plagueSymptomatic PAOD affects approximatelyof the pop ...

ABSTRACT More thanmillion women suffer from pelvic health disordersPHDsin the United Statesa number that is projected to nearly double byThese conditions cost the healthcare system billions annually and negatively affect educational and employment opportunitiesquality of lifeand fertility of patientsWhile studies suggest that PHDs can be managed and improved with educationpractitioners are often c ...

Abstract Depression is common, imposing a tremendous societal burden in terms of cost, morbidity, quality of life, and mortality. The great majority of people with depression are treated in primary care, however outcomes remain poor. There have been two broad attempts to address this problem. One is collaborative care, which uses care managers to coordinate patient care. Collaborative care can be ...

NOTE: These pages contain proprietary/privileged information. SIA requests that they not be released to personsoutside the Government, except for purposes of review and evaluation. Project Summary/Abstract DuraSorb™ is poised to significantly improve the lives of the over 100,000 US women undergoing post- mastectomy breast reconstruction every year. The current standard of care in implant-based ...

This project seeks to develop inhibitors of a novel pancreatic ductal adenocarcinomaPDACprotein targetPDAC remains one of the deadliest cancers with an average survival ofmonths for non resectable tumorsCurrentlya major obstacle in PDAC treatment is that the cells rapidly exhibit resistance to existing untargeted treatment regimens leaving patients with no further optionsStudies indicate that inhi ...

PROJECT SUMMARY Osteoarthritis is today a major worldwide challenge for health systemsrepresenting the most common degenerative joint disorder and the leading cause of chronic disability among older adultsIn the U SaloneOA affectsmillion people and it represents a $billion economic burdenAvailable pharmacological treatments only provide symptomatic pain relief and fail to arrest the progressive de ...