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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Array Based Affinity Selection

    SBC: Tango Biosciences Inc.            Topic: 300

    Project Summary Funds are requested to apply technologies being developed in a current NIGMS award to generate recombinant antibody-like affinity reagents to the spike protein of the SARS-CoV-2 virus. As a proof-of-principle experiment, we have already isolated four fibronectin type III (FN3) monobodies that bind with low nanomolar affinity to the receptor binding domain (RBD) of the viral spike p ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Maximizing the safety profile of a novel cancer therapeutic via the de-immunization of an engineered mammalian asparaginase

    SBC: Enzyme by Design Inc.            Topic: 102

    Project Summary: This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 20-012. The goal of this supplement is to build upon the amazing progress made in the parent Phase 1 SBIR in developing a less immunogenic asparaginase (ASNase) by adding pivotal studies that would demonstrate its reduced immunogenicity, potent anti-ALL action, and superi ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. A single dose long-acting non-addictive polymer conjugate formulation of buprenorphine that provides immediate and prolonged analgesia for post-operative pain

    SBC: SERINA THERAPEUTICS INC            Topic: NINDS

    PAProject Summary Abstract SERis a long acting polymer pro drug of buprenorphine that is being developed to treat postoperative pain following major surgeries such as bunionectomyabdominoplastythoracotomy and knee and hip surgerySERhas no biological activity by itselfbut when administered in vivo by subcutaneous injection it enters the vascular compartment where a plasma esterasebutyrylcholinester ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. SAGE LEAF:Reducing Burden in Alzheimer's Disease Caregivers through Positive Emotion Regulation and Virtual Support

    SBC: BRIGHTOUTCOME INC.            Topic: NIA

    PROJECT SUMMARY The prevalence of Alzheimer’s Disease (AD) and other dementias is steadily climbing and predicted to affect as many as 16 million Americans by 2050. In 2016, 59% of dementia caregivers reported experiencing high levels of emotional and physical stress, and the risk that the chronic stress of dementia caregiving places on caregivers for developing a range of physical and mental he ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Novel oral delivery system for subunit vaccine against ETEC

    SBC: FoodSource Lure Corporation            Topic: NIAID

    Project Summary Abstract Oral vaccines have the potential to make a revolutionary improvement in the quality of life in developing countriesSince these vaccines can be administered by community health workers who are not trained medical personnelthe number of people who can be immunized in a short period of time is drastically increased while the cost per patient is significantly loweredOral vacci ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of group 2 influenza A virus entry inhibitors

    SBC: Chicago Biosolutions, Inc.            Topic: NIAID

    Influenza A viruses belong to the Orthomyxoviridae family with a negative-sense, segmented RNA genome, which can cause seasonal or pandemic flu with high morbidity and significant mortality. Vaccination is the most prevalent prophylactic means for controlling influenza infections. However, an effective vaccine usually takes at least 6 months to develop for the circulating strains. Furthermore, vac ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Fiber-DeliveredProgrammableSupercontinuumLaserAdaptivetoEvolvingNeurophotonicResearch

    SBC: LiveBx, LLC            Topic: 101

    SUMMARY Neurophotonics, including the prominent example of optogenetics, has been the driving force for brain research and one focal area of the NIH BRAIN Initiative established in 2013. In contrast to the genetic and biophotonic advancements that have transformed this field, the progress in laser source technology underlying these advancements has lagged behind, resulting in three technical barri ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Enhanced endothelialization of nanomatrix coated flow diverter for intracranial aneurysms

    SBC: ENDOMIMETICS LLC            Topic: NINDS

    Approximatelyof the population has unruptured cerebral aneurysmsapproximatelymillion people in the USAboutrupture per yearwith devastating consequencesAboutof patients with ruptured aneurysms dieandofwho survive have significant disabilitiesCoil embolization therapy is associated with a high rate of recurrenceFlow diverters are increasingly being used to cover the neck of the aneurysm providing mo ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Development and evaluation of a polymer coated proprietary cream formulation of resiniferatoxin nanoparticles for the treatment of pain associated with Diabetic Peripheral Neuropathy

    SBC: ION CHANNEL PHARMACOLOGY LLC            Topic: 200

    Development and Evaluation of a polymer coated proprietary cream formulation ofresiniferatoxin nanoparticles for the Treatment of Pain Associated with DiabeticPeripheral Neuropathy Diabetes is a major problem in developed and developing countriesIt is estimated thatmillion adults will have diabetes globally by yearOne of the major complications of diabetes is diabetic peripheral neuropathyDPNresul ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Evaluating the completeness of scanning in hand-held whole breast ultrasound exams

    SBC: Metritrack, Inc.            Topic: NCI

    ABSTRACT: The project entails the development of a position-tracking system compatible with existing hand-held ultrasound systems that can track the complete breast volume coverage with a sufficient level of precision to avoid missing small breast cancers. Scanning the entire breast for screening breast cancer gained increased interest in recent years, as it was shown that supplemental screening i ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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