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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Synthetic Training Data for Explosive Detection Machine Learning Algorithms

    SBC: Synthetik Applied Technologies LLC            Topic: HSB0191005

    Deep learning offers a powerful and extensible toolset to achieve or exceed human-level accuracy for automatic object detection in stream of commerce data. However, in order to train deep machine learning-models for 2D and 3D screening a significant quantity of high-quality ground-truth training data is required.We propose SoCPhysics: A Stream-of-Commerce Physics-Based Data Generation Application, ...

    SBIR Phase I 2019 Department of Homeland Security
  2. TOPIC 386: NOVEL ORALLY BIOAVAILABLE PDE-CATENIN INHIBITOR CONCENTRATES IN LUNG FOR CANCER CHEMOPREVENTION

    SBC: ADT Pharmaceuticals, LLC            Topic: NCI

    This application is based on ADT Pharmaceuticalsdiscoveries thatthe cGMP degrading phosphodiesterase isozymephosphodiesteraseAPDEis overexpressed during early stages of tumorigenesisgenetic knockdown of PDEresults in selective apoptosis of tumor cells by activating cGMP PKG signalingandsmall molecule inhibitors of PDEinduce apoptosis by PKG phosphorylation of oncogeniccateninthereby suppressing Tc ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. TOPIC 384: CANCERCOSTDETOX: DETOXING CANCER CARE FINANCIAL TOXICITY

    SBC: BRIGHTOUTCOME INC.            Topic: NCI

    The prohibitive cost of cancer care has been widely describedCancer treatment received by patients with insurance can still result in a considerable financial burdenNon adherence is one of the best studied outcomes resulting from higher care costsFinancial distress has also been linked to changes in treatment related decision makingincluding the decision against a treatment course because of costA ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. STING Inhibitor Discovery for Rare and Common Autoimmune Diseases

    SBC: DISCOVERYBIOMED, INC.            Topic: NIAID

    Principal Investigators for Small BusinessDiscoveryBioMedIncDBMand Nitor TherapeuticsIncNitorProject Summary Abstract The over arching commercial goal for this Nitor TherapeuticsIncNitorand DiscoveryBioMedIncDBMcollaboration is to discover and validate Stimulator of Interferon Genes orSTINGinhibitor ligands in a novel high throughput screeningHTSand validation based Critical Path of bioassaysAberr ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Rodents Derived Synthetic Blood Brain Barrier Models for Chemical Toxicity Screening

    SBC: CFD Research Corporation            Topic: NIEHS

    AbstractThe overall goal of this study is to develop and demonstrate a novelpredictive in vitro organotypicD culture models of the blood brain barrierBBBderived from rodents for chemical toxicity screeningIn contrast with current Transwell based static and microfluidic assaysour commercially available SynBBB model enables real time visualization and quantitation of transport permeation under physi ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of digital and interactive methods to teach immunology

    SBC: FLUID CONTENT INC            Topic: NIGMS

    Abstract The goal of this project is to develop a digital media based program to teach high school student about immunologyWe will develop an interactive digital media to teach minority studentshigh schoolon the introduction of immunology and compare the efficacy of learning between traditional teaching and interactive mediaWe will develop three curriculums to teach group of high school students r ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Device to Measure Pain using Facial Expression Recognition Integrated with Patient PAINReportIt Tablet

    SBC: ENURSING LLC            Topic: NIDA

    Abstract Our goal is to develop a product that will objectively measure pain using computer vision and machine learning technologies together with tablet based self reported pain data from patients for research or clinical purposesOur device will be low cost because it will consist of one or two cameras to record the video and a computer to analyze the video in almost real timeThe software of the ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Amorphous Pharmaceutical Product Development Using Containerless Methods

    SBC: Materials Development, Inc.            Topic: 300

    Amorphous Pharmaceutical Product Development Using Containerless Methods Project Summary The overall objective of this research is to advance drug discovery through preciseengineeringof the structure and properties of API bearing phasesMany emerging drugs cannot be used in their naturally insoluble crystalline forms or they require crystallization in a preferred polymorph in order to be activeIn s ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Targeted Small Molecular Mertansine Delivery for Triple Negative Breast Cancer Treatment

    SBC: Iria Pharma, LLC            Topic: 102

    Project Summary Triple negative breast cancerTNBCis a subtype of breast cancerthat occurs in aboutof diagnosed breast cancerswhich is more likely to affect younger peopleAfrican AmericansHispanicsand or those with BRCAgene mutationThe projected TNBC annually diagnosed cases in United States are estimated to be more thanbyDue to the lack of the identified receptors on tumor cell surfaceTNBC patient ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a High-Throughput Magnetic Cytometer for Single Cell Sorting

    SBC: Microsensor Labs, LLC            Topic: 400

    Project Summary This Small Business Innovation Research Phaseproject will develop a novel magnetic cytometer to rapidly isolateidentify and sort single intact and viable cells from heterogeneous cell population for single cell analysisSingle cell analysis is the key to investigate fundamental biological principles behind cell heterogeneity and disease evolutionSorting of single cells from heteroge ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

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