Award Data

DESCRIPTION (provided by applicant): Our goals in Phases I and II have been completed and showed the feasibility of our approach for assessing brain vascular autoregulatory responses to hypoxic stimuli. Frequency Domain Near-Infrared Spectroscopy offers the advantage of performing safe, non-invasive, transcranial, quantitative, real time measurements of cerebral hemodynamics and oxygenation. Our ...

DESCRIPTION (provided by applicant): Alzheimer disease (AD) is the most common neurodegenerative disease in the elderly. To date, no satisfactory treatment is available for AD. One of the pathological hallmarks of AD is deposits of amyloid protein (Aa) in neuritic plaques and cerebral vessels. Increasing lines of evidence support the notion that Aa and its precursor (APP) play pathogenetic roles i ...

Project Summary Abstract Irritable Bowel Syndrome IBS is a chronic and costly digestive condition characterized by abdominal pain and altered bowel habits diarrhea constipation or mixed type IBS is a disorder of brain gut dysregulation including the amplification of normal gut signals at the level of the brain Yet most medical therapies for IBS to date have focused on symptom management and dietar ...

DESCRIPTION provided by applicant DiscoveryBioMed Inc DBM completed recently Phase I SBIR funded goals milestones specific experimental aims and efforts to screen synthetic organic small molecules on immortalized and primary differentiated human adipocyte platforms and to validate the high throughput screening HTS based Drug Discovery output with a Critical Path of bioassays dete ...

Preterm birthPTBdelivery prior toweeks gestational ageaccounts forof all births and remains the leading cause of neonatal deathThe majority of PTB is preceded by spontaneous preterm laborPTLCurrentlythere is a major unmet need for methods to identify women at risk of PTL and provide an early warning system for potential interventionhome uterine monitoringHUMis one approach that has shown some prom ...

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DESCRIPTION provided by applicant This proposed Phase II project will lead to a commercial product capable of transfecting individual target cells This new biotool uses a patented microfabricated chip called a nanofountain probe NFP to deliver molecules into live individual target cells by single cell electroporation which induces temporary nanopores in the cell membrane via the applicat ...

DESCRIPTION (provided by applicant): Mycotoxins are toxic compounds produced by fungi that contaminate crops during growth, transportation, or storage. Contamination of food and feed by mycotoxigenic fungi is an important agricultural and national security concern. For example, thousands of people are sickened annually by mycotoxicoses related to crops contaminated with fungi, and the safety of th ...

Ebola (EBOV) and Marburg (MARV) viruses belong to the Filoviridae family and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction after an incubation period of 4-14 days. Due to safety concerns, these viruses are designated as biosafety level 4 agents. Currently, there is no effective vaccine or therapeutic treatment for filoviral infections in humans. Africa has recen ...

Amorphous Pharmaceutical Product Development Using Containerless Methods Project Summary The overall objective of this research is to advance drug discovery through precise “engineering” of the structure and properties of API-bearing phases. Many emerging drugs cannot be used in their naturally insoluble crystalline forms or they require crystallization in a preferred polymorph in order to be ...