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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Biphase Extended Release Tablet Formulation for Nerve Agent Pretreatment

    SBC: ZYMERON CORP            Topic: CBD181004

    Nerve agents exert their toxic effect by binding to and inactivating enzyme acetylcholinesterase, a key enzymatic regulator of cholinergic neurotransmission. The binding becomes irreversible after a varying amount of time with nerve agents and this aging process limits the treatment window of oxime reactivators. To enhance the current antidote treatment of nerve agent autoinjectors, a pyridostigmi ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  2. Bi-specific Antibodies Targeting Disease Caused by Encephalitic Alphaviruses

    SBC: BRHMS LLC            Topic: CBD181007

    Highly pathogenic alphaviruses like VEEV/EEV/WWEEV cause encephalitis in humans and equids. These infections are endemic in wide regions of the developing world. Translational research regarding these pathogens is focused on developing new strategies to detect, treat and ideally protect humans and animals from these infections. Gene-encoded antibodies against alphavirus E1/E2 surface proteins will ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  3. Chemical Warfare Agent (CWA) Lightweight Field-Portable (Hand-Held) Medical Diagnostic Tool

    SBC: RAPID PATHOGEN SCREENING, INC.            Topic: CBD06104

    Various methods and techniques have been developed in the laboratory for the detection and identification of exposure to chemical warfare nerve agents (CWNAs). A broad range of analytical methods is available to screen urine, blood or body tissues for traces of CWNAs or their breakdown products. Laboratory-based methods allow the differentiation between CWNAs and non-CWNAs that are used in agric ...

    SBIR Phase I 2006 Department of DefenseOffice for Chemical and Biological Defense
  4. Chemical Warfare Agent (CWA) Lightweight Field-Portable (Hand-Held) Medical Diagnostic Tool

    SBC: SEMOREX, INC.            Topic: CBD06104

    Chemical weapon nerve agents (CWNAs) are extremely deadly substances, and as a key element in the arsenals of rogue nations and terrorists who are willing to use them, they represent a constant threat to our military and civilian personnel. Current methods for detecting CWNA exposure in individuals have many deficiencies, including excessive false-positives (triggered by pesticides) and false-neg ...

    SBIR Phase I 2006 Department of DefenseOffice for Chemical and Biological Defense
  5. Computer-Assisted Strain Construction And Development Engineering (CASCADE)

    SBC: GENOMATICA, INC.            Topic: CBD06107

    The recent advances of modern high-throughput genomic technologies have resulted in a large number of fully sequenced microbial organisms. The construction of these comprehensive metabolic models serves many purposes including encapsulating all the data and allowing for in silco experiments to be performed that can drive experimental work and aid in strain development and optimization. The creatio ...

    SBIR Phase I 2006 Department of DefenseOffice for Chemical and Biological Defense
  6. Computer-Assisted Strain Construction And Development Engineering (CASCADE)

    SBC: QUANTUM INTELLIGENCE, INC.            Topic: CBD06107

    This proposal aims at solving for a “Computer-Assisted Strain Construction and Development Engineering (CASCADE)” (SBIR CBD06-107). Our approach is to integrate BioSpice (a DOD product) and our statistical model developed by Quantum Intelligence together with publicly available data to develop a system for discovering the predictive relations between genomic fingerprints of an organism and it ...

    SBIR Phase I 2006 Department of DefenseOffice for Chemical and Biological Defense
  7. Concurrent identification of Natural Antibiotics-Producing Gene Clusters and Culture Conditions

    SBC: Carrera Bioscience Inc.            Topic: CBD152004

    Modern metagenomics studies on diverse microbiomes revealed immense repertoires of potential natural products/antibiotics to be tapped into.However, identifying such secondary metabolites (SMs) directly from a complex microbiome remains rarely successful due to two major technicalchallenges: i) difficulty in dissecting complex microbiome samples and massive metagenomics data, and ii) difficulty in ...

    SBIR Phase I 2015 Department of DefenseOffice for Chemical and Biological Defense
  8. Dual Formulation of Atropine and Scopolamine with Enhanced Stability

    SBC: Nano Terra, Inc.            Topic: CBD181005

    The standard US military treatment for nerve agent exposure is application of up to three autoinjectors, each containing atropine sulfate and 2-pralidoxime, to counteract symptoms of nerve agent intoxication and restore acetylcholinesterase activity. This treatment increases survival rates after nerve agent exposure, however, seizures resulting from nerve agent poisoning are a common symptom that ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  9. Dual Formulation of Atropine/Scopolamine with Enhanced Stability

    SBC: CMC PHARMACEUTICALS INC            Topic: CBD181005

    CMC Pharmaceuticals, Inc. (Cleveland, OH) is proposing developing a stable, combination product of two small molecule drug candidates as a counter measure to chemical warfare nerve agents (NA). The combination product is expected to exploit complementary pharmacological profiles for optimal muscarinic receptor blockade and anticholinergic activity within the peripheral and central nervous system. ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  10. Durable Stretch Barrier Materials

    SBC: LUNA INNOVATIONS INCORPORATED            Topic: CBD181003

    The proliferation of weapons of mass destruction (WMDs) presents a serious security threat to U.S. and allied personnel around the world. Military personnel and first responders must be prepared to operate under a wide range of chemical, biological, radiological, nuclear (CBRN) threats. Commercially available CBRN protective suits are bulky offering little dexterity to the wearer, therefore new st ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
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