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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Extended Release of Pyridostigmine Bromide for Effectively Combating Nerve Agent Exposure

    SBC: Innosense Llc            Topic: CBD181004

    Chemical warfare agents such as the lethal nerve agent soman are a major source of risk to military personnel. Currently, pyridostigminebromide (PB) is the only FDA-approved pretreatment to counteract the effects of soman. The rationale behind PB administration is that it actsas a temporary inhibitor of AChE. This precludes nerve agents from irreversible inactivation of AChE, thereby mitigating th ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  2. Biphase Extended Release Tablet Formulation for Nerve Agent Pretreatment

    SBC: Zymeron Corporation            Topic: CBD181004

    Given the unforeseen/unanticipated use of nerve agents in the battlefield and on the homeland, military personnel can benefit from this oncedaily pretreatment. It may also be desirable to pretreat certain medical and emergency aid personnel following a known/suspected nerveagent attack. Also, a novel, improved PB extended release formulations can be commercialized for the treatment of myasthenia g ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  3. Dual Formulation of Atropine and Scopolamine with Enhanced Stability

    SBC: Nano Terra, Inc.            Topic: CBD181005

    The standard US military treatment for nerve agent exposure is application of up to three autoinjectors, each containing atropine sulfate and2-pralidoxime, to counteract symptoms of nerve agent intoxication and restore acetylcholinesterase activity. This treatment increases survivalrates after nerve agent exposure, however, seizures resulting from nerve agent poisoning are a common symptom that ca ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  4. Dual Formulation of Atropine/Scopolamine with Enhanced Stability

    SBC: Cmc Pharmaceuticals, Inc.            Topic: CBD181005

    CMC Pharmaceuticals, Inc. (Cleveland, OH) is proposing developing a stable, combination product of two small molecule drug candidates as acounter measure to chemical warfare nerve agents (NA). The combination product is expected to exploit complementary pharmacologicalprofiles for optimal muscarinic receptor blockade and anticholinergic activity within the peripheral and central nervous system. It ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  5. A Low-Swap Powered Air Purifying Respirator (PAPR)

    SBC: CREARE LLC            Topic: CBD181002

    Creare has developed compact, high-efficiency blowers and comfortable, low-leakage closures for chem-bio protective gear that will enabledevelopment of a powered air purifying respirator (PAPR) with a high protection factor and low size, weight, and power consumption (SWaP).Our system will provide higher protection factors than conventional PAPR technology and be much more comfortable to wear than ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  6. HIGH STRETCH, ENVIRONMENTALLY ROBUST HYBRIDSIL PERFLUOROELASTOMER BARRIERCOMPOSITES FOR CBRN PROTECTIVE ENSEMBLES

    SBC: Nanosonic Inc.            Topic: CBD181003

    Through the proposed SBIR program, NanoSonic will design, empirically validate, and commercially transition durable, high stretch HybridSilbarrier composites for next-generation CBRN protective ensembles. NanoSonic's durable HybridSil stretch barrier composites will bemolecularly designed and empirically optimized to provide a previously unavailable combination of biaxial isotropic stretch for wea ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  7. Durable Stretch Barrier Materials

    SBC: LaunchBay LLC            Topic: CBD181003

    Chemical, Biological, Radioactive and Nuclear (CBRN) protective ensembles are widely used by the US Military and civilian first responders asthe first line of defense for personnel working in contaminated environments. Many innovative products have been developed for thechemical protective clothing market in response to demand from the market place for improved performance. However, the need forte ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  8. Photoacoustic Gasses Optical Detector and AnalyzerPhotoacoustic Gasses Optical Detector and Analyzer

    SBC: PHYSICAL OPTICS CORPORATION            Topic: CBD171004

    To address the CBDs need for real-time analytical technology for multicomponent vapor identification and quantification, Physical OpticsCorporation (POC) proposes to continue the development of a new Photoacoustic Gasses Optical Detector and Analyzer (PAGODA)autonomous, network-enabled photoacoustic spectrometer (PAS) for the correlation, analysis, and identification of measured spectra. In thePha ...

    SBIR Phase II 2019 Department of DefenseOffice for Chemical and Biological Defense
  9. Open-Path Spatial Ring Down Spectrometer for Chemical Vapor Detection

    SBC: Physical Sciences Inc.            Topic: CBD171004

    Physical Science Inc. (PSI) will develop a new approach to chemical vapor detection based on a novel open-path sample cell design. The PhaseI system level model predicts SNR supporting a probability of detection of 95% and a MTBFA of 168 hours for all relevant CWAs and TICs at the10 minute negligible MEG level at a 20 s measurement time. In addition to robust detection, the system design can provi ...

    SBIR Phase II 2019 Department of DefenseOffice for Chemical and Biological Defense
  10. Efficient Materials for Optical Cryocoolers

    SBC: ThermoDynamic Films LLC            Topic: CBD171001

    This Phase-II SBIR proposal directly addresses the need to improve the size, weight and power, SWaP, of optical cryocoolers. In particular, theproposers will work toward increasing the efficiency of optical cryocoolers by incorporating cooling materials that require less input laserpower to achieve a given heat lift. The new cooling materials will be high-purity crystals doped with active rare-ear ...

    SBIR Phase II 2019 Department of DefenseOffice for Chemical and Biological Defense

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