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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Extended Release of Pyridostigmine Bromide for Effectively Combating Nerve Agent Exposure

    SBC: Innosense Llc            Topic: CBD181004

    Chemical warfare agents such as the lethal nerve agent soman are a major source of risk to military personnel. Currently, pyridostigminebromide (PB) is the only FDA-approved pretreatment to counteract the effects of soman. The rationale behind PB administration is that it actsas a temporary inhibitor of AChE. This precludes nerve agents from irreversible inactivation of AChE, thereby mitigating th ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  2. Photoacoustic Gasses Optical Detector and AnalyzerPhotoacoustic Gasses Optical Detector and Analyzer

    SBC: PHYSICAL OPTICS CORPORATION            Topic: CBD171004

    To address the CBDs need for real-time analytical technology for multicomponent vapor identification and quantification, Physical OpticsCorporation (POC) proposes to continue the development of a new Photoacoustic Gasses Optical Detector and Analyzer (PAGODA)autonomous, network-enabled photoacoustic spectrometer (PAS) for the correlation, analysis, and identification of measured spectra. In thePha ...

    SBIR Phase II 2019 Department of DefenseOffice for Chemical and Biological Defense
  3. Mycotoxin Neutralization Treatment

    SBC: PHYSICAL OPTICS CORPORATION            Topic: CBD152003

    To address the Chemical and Biological Defense programs (CBDs) need for medical countermeasures against mycotoxin intoxication, PhysicalOptics Corporation (POC) proposes to develop a new Mycotoxin Neutralization Treatment (MyNT). This proposed solution is based on neutralizingmycotoxin from its deleterious effects by acting on multiple levels of mycotoxin metabolism through the novel combination o ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  4. Exploiting Microbiome and Synthetic Biology to Discover and Produce Naturally Occurring Antibiotics

    SBC: Radiant Genomics, Inc.            Topic: CBD152004

    In this proposal, we aim to validate the human gut microbiome and arid soil as a source of antibiotic natural products (NPs ) by using ametagenomic NP discovery platform developed at Radiant Genomics. Recent studies suggest that the genomes of uncultivated microorganisms,like their cultivated counterparts, encode an enormous number of NPs. Gaining systematic access to NPs using standard, cultivati ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  5. Wavelet-Based Approach for Signal Processing and Analysis

    SBC: PHYSICAL OPTICS CORPORATION            Topic: CBD152006

    To address CBDs need for development of analytical approaches to fuse sensor data from multiple modalities to provide common operationalpictures in threat environments, Physical Optics Corporation (POC) proposes to develop a Wavelet-based Approach for Signal Processing andAnalysis (WASP). WASP is based on novel application of wavelet-based analysis to multimodel, multidimensional data available fr ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  6. Signal Processing for Layered Sensing

    SBC: TOYON RESEARCH CORPORATION            Topic: CBD152006

    As a foundational component of a Layered Sensing architecture, Toyon proposes to develop a Multi-Modal Fusion Module (M2FM) capable ofconfirming detections from Chemical, Biological and Radiological (CBR) sensing networks by fusing together information from other (non-CBR)sensors. The module will provide information to assist operators in confirming an initial CBR detection or rejecting it as a fa ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  7. Computer-Assisted Strain Construction And Development Engineering (CASCADE)

    SBC: GENOMATICA, INC.            Topic: CBD06107

    The recent advances of modern high-throughput genomic technologies have resulted in a large number of fully sequenced microbial organisms. The construction of these comprehensive metabolic models serves many purposes including encapsulating all the data and allowing for in silco experiments to be performed that can drive experimental work and aid in strain development and optimization. The creatio ...

    SBIR Phase I 2006 Department of DefenseOffice for Chemical and Biological Defense
  8. Handheld Instrument for Nerve Agent Detection

    SBC: KUMETRIX, INC.            Topic: CBD06104

    Rapid detection and identification of chemical warfare nerve agents (CWNAs) are critical to the screening and subsequent treatment of exposed warfighters. Inhibition of cholinesterase activity is insufficient as a marker of exposure to CWNAs, in that it can give misleading results and does not distinguish CWNAs from commonly employed pesticides. This proposal presents a revolutionary field-porta ...

    SBIR Phase I 2006 Department of DefenseOffice for Chemical and Biological Defense
  9. Computer-Assisted Strain Construction And Development Engineering (CASCADE)

    SBC: QUANTUM INTELLIGENCE, INC.            Topic: CBD06107

    This proposal aims at solving for a “Computer-Assisted Strain Construction and Development Engineering (CASCADE)” (SBIR CBD06-107). Our approach is to integrate BioSpice (a DOD product) and our statistical model developed by Quantum Intelligence together with publicly available data to develop a system for discovering the predictive relations between genomic fingerprints of an organism and it ...

    SBIR Phase I 2006 Department of DefenseOffice for Chemical and Biological Defense
  10. Continuously Variable Attenuated-Phase-Shifted Photomask for Integrated Spectroscopic Sensor Platforms enabled by Optical Nanolithography

    SBC: Redondo Optics, Inc.            Topic: CBD05107

    Redondo Optics Inc. (ROI), a world leader in engineering and manufacturing of leading-edge nano-materials, optical sensors, fiber and integrated optics, and advanced photonics instrumentation proposes to develop and demonstrate for the first time the concept of an etch-less, deep-UV, fully continuously variable attenuated-phase-shifted mask (ConvaPSM™) technology to enable ultra-high resolution, ...

    SBIR Phase II 2006 Department of DefenseOffice for Chemical and Biological Defense

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