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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Micronized salsalate in a parenteral formulation is a safe and effective analgesic for acute postoperative pain management
SBC: RH NANOPHARMACEUTICALS L.L.C. Topic: 101SUMMARY: The White House has initiated an aggressive campaign to combat the current opioid crisis that is affecting all levels of the American way of life. The opioid crisis has emerged from multiple fronts. Among these various fronts, the continued use of opioids in the post-operative area is a growing addiction risk. Current post- operative pain management utilizes a multimodal pain management s ...
SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Long-term therapeutic effects of synthetic bryostatin-1 in advanced AD without memantine
SBC: SYNAPTOGENIX, INC. Topic: RProgram Director/Principal Investigator (Last, First, Middle): Miao-Kun Sun Project Summary/Abstract The importance of memory impairment and dementias, including Alzheimer’s disease (AD), as a global priority has been well recognized. Many compounds that target AD pathologies have been developed preclinically but have failed in clinical trials, mostly for the lack of therapeutic efficacies.Neuro ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Rapid and Effective Localized Neurovascular Cooling Using the Khione Insulative Catheter
SBC: Tom L Merrill Topic: 101Project Summary Stroke is the 5th leading cause of death and number one cause of adult disability in the United States. The primary goal of acute ischemic stroke (AIS) treatment is quickly restoring blood perfusion. However, studies have shown that this return of blood flow, while necessary, can also cause damage to local tissue leading to poor patient outcomes. Therapeutic hypothermia (TH) has be ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Screen molecules modulating MOR trafficking with a newly developed MOR/14-3-3 bioassay.
SBC: BIOINVENU CORPORATION Topic: NIDASpecific AimValidate the MORLinkLight assay with a pilot HTS to identify molecules modulating MOR traffickingSignificanceThe current crisis of opioid use disordersOUDsand opioid overdose deaths in the United States urgently demands safer and better therapeuticsTo develop better and safer therapeutic agents for the treatment of OUDsfirst and foremost is to have new bioassays which are different fro ...
SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Prevention of arthritis-induced bone erosion by inhibiting osteoclast differentiation by the haloanilide, N-Methyl Dichloropropionaniline
SBC: ExesaLibero Pharma Topic: NIAMSWe are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and jointsInflammatory arthritis disables thousands of people each yearIt occurs in children and adultsafter trauma and infections but most cases are idiopathicMillions of adults live with chronic RAwhich has similar featuresInflammatory arthritis often requires trea ...
STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
An Integrated Genetic-Epigenetic Tool for the Prediction of CHD Incidence in African-Americans
SBC: Cardio Diagnostics, LLC Topic: NHLBIABSTRACTHeart disease is the leading cause of death in the United StatesCoronary heart diseaseCHDis the most common type of heart diseaseEvery yearmillions of Americans suffer otherwise preventable cardiac events resulting indeaths and $billion dollars of economic damage each yearThe prevalence of CHD varies by ethnicityNeverthelessfortunatelyCHD related morbidity and mortality can be prevented th ...
SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Targeting SWELL1 Signaling to Treat Obesity-Induced Type 2 Diabetes
SBC: Senseion, LLC Topic: 200Project Summary Abstract TypediabetesT Dis characterized by both a loss of insulin sensitivity of target tissuesfatskeletal muscleliverand ultimatelyimpaired insulin secretion from the pancreaticcellWe have identified a novel SWELLmediated signaling pathway that regulates both insulin sensitivity and insulin secretionwhereby SWELLloss of function can both negatively regulate insulin signaling in t ...
SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Phase 1 cross over biodistribution study of [203Pb]VMT01 for single photon emission computed tomography (SPECT) and [68Ga]VMT02 for positron emission tomography (PET) imaging of stage 4 melanoma
SBC: VIEWPOINT MOLECULAR TARGETING, INC. Topic: 102SIGNIFICANCE: Melanoma incidence is rising faster than any other cancer and metastatic melanoma is typically fatal. Responses to targeted and immunotherapies can be remarkable, but low response rates, acquired resistance, and adverse side effects limit long-term quality of life for these patients. The overall response rate to all therapies remains dismally near 50% and the 5-year survival is andlt ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
PreImplantation Factor plus hypothermia to treat neonatal brain injury
SBC: BioIncept, LLC Topic: NICHDABSTRACTPerinatal hypoxic ischemic encephalopathyHIEaffectstoinfants per everybornMortality from HIE can be up toand approximatelyof survivors suffer significant longterm disability including cerebral palsyepilepsyand developmental disordersDamage during the acute phase of HIE is caused by a deficit in oxygen and glucose in the brainHoweverincreasing evidence indicates that secondary and tertiary ...
STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Performance Evaluation of a non-Degradable Synthetic Device for Chondral and Osteochondral Defects of the Knee
SBC: Hydro-Gen LLC Topic: NIAMSInjury to joints can lead to painful defects in articular cartilage and the underlying bone, which adversely affect the function and biological health of the entire joint. Current solutions for cartilage (chondral) and cartilage-and- bone (osteochondral) defects, are unreliable, are technically challenging, and often require multiple procedures. A surgeon-engineer-biologist team at Hospital for Sp ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health