Award Data

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Micronized salsalate in a parenteral formulation is a safe and effective analgesic for acute postoperative pain management

    SBC: RH NANOPHARMACEUTICALS L.L.C.            Topic: 102

    SUMMARYThe White House has initiated an aggressive campaign to combat the current opioid crisis that is affecting all levels of the American way of lifeThe opioid crisis has emerged from multiple frontsAmong these various frontsthe continued use of opioids in the post operative area is a growing addiction riskCurrent postoperative pain management utilizes a multimodal pain management strategywhich ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Long-term therapeutic effects of synthetic bryostatin-1 in advanced AD without memantine

    SBC: Neurotrope Bioscience, Inc.            Topic: R

    Program Director Principal InvestigatorLastFirstMiddleMiao Kun Sun Project Summary Abstract The importance of memory impairment and dementiasincluding Alzheimer s diseaseADas a global priority has been well recognizedMany compounds that target AD pathologies have been developed preclinically but have failed in clinical trialsmostly for the lack of therapeutic efficaciesNeurotrope Bioscience Incis ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Rapid and Effective Localized Neurovascular Cooling Using the Khione Insulative Catheter

    SBC: Tom L Merrill            Topic: 101

    Project Summary Stroke is theth leading cause of death and number one cause of adult disability in the United StatesThe primary goal of acute ischemic strokeAIStreatment is quickly restoring blood perfusionHoweverstudies have shown that this return of blood flowwhile necessarycan also cause damage to local tissue leading to poor patient outcomesTherapeutic hypothermiaTHhas been shown to be a robus ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Screen molecules modulating MOR trafficking with a newly developed MOR/14-3-3 bioassay.

    SBC: BIOINVENU CORPORATION            Topic: NIDA

    Specific AimValidate the MORLinkLight assay with a pilot HTS to identify molecules modulating MOR traffickingSignificanceThe current crisis of opioid use disordersOUDsand opioid overdose deaths in the United States urgently demands safer and better therapeuticsTo develop better and safer therapeutic agents for the treatment of OUDsfirst and foremost is to have new bioassays which are different fro ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Prevention of arthritis-induced bone erosion by inhibiting osteoclast differentiation by the haloanilide, N-Methyl Dichloropropionaniline

    SBC: ExesaLibero Pharma            Topic: NIAMS

    We are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and jointsInflammatory arthritis disables thousands of people each yearIt occurs in children and adultsafter trauma and infections but most cases are idiopathicMillions of adults live with chronic RAwhich has similar featuresInflammatory arthritis often requires trea ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. PreImplantation Factor plus hypothermia to treat neonatal brain injury

    SBC: BioIncept, LLC            Topic: NICHD

    ABSTRACTPerinatal hypoxic ischemic encephalopathyHIEaffectstoinfants per everybornMortality from HIE can be up toand approximatelyof survivors suffer significant longterm disability including cerebral palsyepilepsyand developmental disordersDamage during the acute phase of HIE is caused by a deficit in oxygen and glucose in the brainHoweverincreasing evidence indicates that secondary and tertiary ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Performance Evaluation of a non-Degradable Synthetic Device for Chondral and Osteochondral Defects of the Knee

    SBC: Hydro-Gen LLC            Topic: NIAMS

    Injury to joints can lead to painful defects in articular cartilage and the underlying bonewhich adversely affect the function and biological health of the entire jointCurrent solutions for cartilagechondraland cartilage andboneosteochondraldefectsare unreliableare technically challengingand often require multiple proceduresA surgeon engineer biologist team at Hospital for Special SurgeryHSSdedica ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. 3D-Printed Superhydrophobic-Tipped Optical Fiber for Targeted Periodontal Photodynamic Therapy

    SBC: SingletO2 Therapeutics LLC            Topic: NIDCR

    Project Summary Abstract Eradication of bacteria located in periodontal pockets presents a daunting challenge to dentists and oral care professionalsThe problem is significantsevere periodontitis is theth most prevalent disease worldwide with overmillion people affectedThe global cost of lost productivity from severe periodontitis is estimated to be $billion USD yearAntibiotics with scaling and ro ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Denaturation-Free DNA Target Enrichment and Direct Sequencing of Large Chromosomal Segments

    SBC: GENERATION BIOTECH, LLC            Topic: 172

    SummaryThird generationlong read sequencing technologies are increasingly sought after for the analysis of difficult genomic regionssuch as the major histocompatibility complexMHCthe human leukocyte antigenHLAloci and genomes of cancerspathogens and viral insertionsas well as plant and animal genomesSuch methods provide researchers with more contextual informationenabling analysis of highly comple ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Home-based Virtual Reality System for the Treatment of Chemotherapy-related Cognitive Impairments

    SBC: Bright Cloud International Corp            Topic: 102

    PROJECT SUMMARY ObjectivesTo develop a computer based cognitive training system for breast cancer survivors who are suffering from cognitive impairments subsequent to chemotherapyA home based system will be developedtargeting executive functionsattention and memory cognitive domainsThe system will incorporate a novel low cost biosensor deviceSpecific AimsDevelopmentvalidation and usability evaluat ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
US Flag An Official Website of the United States Government