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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. TOPIC 369: NOVEL DOSING AND DISPENSING SYSTEM FOR MULTIPARTICULATE CANCER DRUGS

    SBC: HS-DESIGN, INC            Topic: NCI

    Oncology drugs continue to advance at a rapid pace with many therapies delivered orally as tablets or capsulesSmaller childrenhowevercannot swallow tablets or capsulesFor these drugs to be used in the pediatric population they need to be reformulatedTraditionally this has meant creating a liquid suspensionchewableor rapid dissolve tabletCancer medicationshoweveroften have terrible taste profiles t ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. TOPIC 393: BREATH TEST FOR BIOMARKERS OF RADIATION EXPOSURE

    SBC: MENSSANA RESEARCH INC            Topic: NCI

    The problemPatients receiving therapeutic radiation are at risk of adverse toxic effectsThese adverse events are usually unpredictable and may result in severe morbidity or mortalityExampleA third or more of patients receiving chest radiation for cancers of lung may develop life threatening acute radiation pneumonitisThe clinical needThere is a clinical need for an objective test to estimate the b ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Radiation Sterilizable, RFID Tagged Vials for Biomedical Samples

    SBC: BIOTILLION LLC            Topic: OD

    Abstract The Specific Aim of this Phase IIb (Phase II competitive renewal) SBIR proposal is to advance the prototypes we developed under our Phase I and II SBIR grants into commercial production. We will produce SBS-96 format radiation sterilizable electronically tagged sample vials that can be read at ultra-low temperatures. Hundreds of millions of SBS-96 vials are sold each year and each of thes ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Optimal channel and lever sampling of duodenoscopes for culture using portable Two-Phase Flow technology

    SBC: Novaflux Inc.            Topic: NIAID

    Project Summary Abstract Outbreaks associated with contaminated duodenoscopes are still occurring at high ratesRecent clinical studies evaluating patient used endoscopes reported that culture endoscope contamination rates range from andltup toExperts now recognize that there is an urgent need for an inexpensive and highly reliable sampling method to check on the adequacy of reprocessing duodenosco ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Framework for Biomolecular Optimization and Design Using a New Poisson-Boltzmann Description

    SBC: CONTINUUM DYNAMICS INC            Topic: 400

    Rational drug design holds the potential for developing more effective drugs in shorter time frames than traditional trial and error approachesAccordinglysoftware tools are needed that automate the search process and can computationally direct the changes in ligand geometry and charge distribution to selectively bind at specified receptor sitesSuch analysis entails two componentsa module that eval ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a novel therapy for mitigation of the irradiation-inducedgastrointestinal syndrome

    SBC: BioIncept, LLC            Topic: NIAID

    Accidental radiation exposure as a result of terrorismindustrial accidentsor military actions is an increasing global threatExposure to IR in the dose range ofGy andGy toGy results in development of the hematopoieticHand gastrointestinalGIsubsyndromesrespectivelyof the acute radiation syndromeARSThe GI syndrome that follows GI ARS is the leading cause of death following higher doses of radiation e ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Tactile and ultrasound imaging fusion for functional assessment of the female pelvic floor

    SBC: ADVANCED TACTILE IMAGING INC            Topic: NICHD

    SUMMARY Pelvic organ prolapsePOPis a highly prevalent condition affecting at leastof women in the US during their lifetimesUrinary incontinenceUIas found in the US surveyaffects fromtoof womenThe true etiology of POP and UI and variations seen among individuals are not entirely understoodThese disorders are thought to share a common pathogenesisweakeningelasticity changesof the muscular and connec ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Novel fluorescent biosensors to continuously visualize real-time protein phosphorylation in live cells

    SBC: Lucidicor Inc.            Topic: 400

    Project SummaryProtein phosphorylation plays an essential role in orchestrating the myriad aspects of cell functionKinaseswhich phosphorylate proteinsare encoded byof the human genome and are critically involved in diverse conditions such as cancermetabolic disorders and neurodegenerationCurrent scientific tools for detecting cellular phosphorylation are limitedbecause most tools examine this proc ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. The use of selective NaV1.7 inhibitors to treat inflammation post-surgery

    SBC: CHROMOCELL CORPORATION            Topic: NIAID

    ABSTRACTNonsteroidal anti inflammatory drugsNSAIDsare the most commonly prescribed drugs to treat posttraumatic inflammation and painalthough they carry significant risk of seriousdose dependent adverse eventsCorticosteroidswhich are an alternative class of anti inflammatory drugsare rarely prescribed for post traumatic inflammationdue to adverse effects on wound healing and their lack of specific ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Adenylyl Cyclase Type 5 Inhibition to Treat Myocardial Infarction

    SBC: VASADE BIOSCIENCES, INC.            Topic: NHLBI

    PROJECT SUMMARY/ABSTRACT The most significant advance in the treatment of Myocardial Infarction (MI) has been reperfusion therapy, which must be applied immediately after the MI diagnosis has been made. Despite the thousands of studies on drug therapies designed to reduce the size of the MI, most have failed in clinical trials. Our hypothesis is that a major reason why these drugs failed is that t ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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