Award Data

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is the development of new tools to reduce transmission of SARS-CoV-2 virus and the associated COVID-19 pandemic. The materials platform developed in

A critical bottleneck in machine learning efforts continues to be either the lack of sufficiently sized, fully curated data-sets, or availability of the time and resources required to develop the required data-sets/models via manual identification and tagging. Because large curated data-sets are essential to ship identification and classification using machine learning, Rite-Solutions proposes an ...

LambdaVision has developed a protein-based retinal implant to restore vision to the millions of people blinded by retinal degenerative diseases, including retinitis pigmentosa and age-related macular degeneration. Preclinical evaluation of the technology demonstrated the ability to reproducibly stimulate degenerated retinal tissue and safely insert the implant into the subretinal space of both rat ...

In order to achieve the long duration manned deep-space missions, NASA created the Spacecraft Oxygen Recovery (SCOR) project aiming to increase the oxygen recovery of the Sabatier technology from 50% to 75-100%, and the Game Changing Development Program has been seeking techniques addressing ldquo;Advanced Oxygen Recovery for Spacecraft Life Support Systemsrdquo;. Space oxygen recovery technologie ...

PROJECT SUMMARY / ABSTRACTRobust nonclinical data is an absolute requirement for building an effective translational strategy and developing clinically safe and effective medications. Most current efforts to facilitate generation of robust nonclinical research data focus on producing guidelines and checklists pertaining to study design and data analysis, but: a) do so only from a reporting perspec ...

ABSTRACTNon-alcoholic fatty liver disease (NAFLD) refers to a spectrum of diseases related to metabolic syndrome that are characterized by steatosis, the accumulation of fat within the liver. Non-alcoholic steatohepatitis (NASH), the most aggressive NAFLD subtype, refers to the presence of inflammation and necrosis in a background of steatosis, and is associated with hepatic fibrosis. NASH is a se ...

PROJECT SUMMARY/ABSTRACT Nucleic acids (NA) have a broad and expanding therapeutic potential, but a major limiting factor remains the difficulty to deliver these molecules. We have developed a highly scalable platform technology with the capacity for delivering NAs for use in multiple disease systems. Our goal is to adapt this technology to deliver small interfering RNA (siRNA) precursor form, sho ...

ABSTRACT Suicide is a top ten cause of death in the US and rates of suicide have increased steadily for the last twenty years. Despite this, there is a paucity of research on treatment programs designed to reduce suicide attempts and none that include a digital therapeutic. In this Phase I SBIR application Oui Therapeutics, LLC proposes a project to: 1) create a beta version of the Oui app (called ...

SUMMARY/ABSTRACT An estimated 5.6 million patients are currently living with Alzheimer’s disease and have no disease modifying therapies available. Without any major breakthroughs in identifying transformative treatments, the burden of patient care costs to the United States healthcare system is expected to skyrocket as our population ages. The clinical pipeline in Alzheimer’s disease has been ...

Power and energy are fundamental to all vehicles, and there are problems with today’s propulsion systems: batteries have low energy density relative to fuel, and today’s combustion engines are not reliable, efficient or quiet, and Diesel engines are particularly heavy. In order to create a more practical and dependable heavy-fueled propulsion system for Group 2 and Group 3 UAS, which address t ...