Award Data

Aerosols represent one of the more efficient methods to distribute biological and chemical agents throughout the atmosphere. Small aerosol droplets can be readily inhaled and easily penetrate deep into the lungs where they lodge in bronchial alveoli. Within the alveoli, chemical and biological agents can breach epithelial and endothelial cell layers and enter the bloodstream, where they cause da ...

The primary objective of this effort is to design and develop a database management system (DBMS) and enable the integrated interpretation of the vast amounts of genomic and proteomic data in proper biological context. This DBMS will enable the development of diagnostic assays for human exposure to specific biological threat agents using an existing suite of systems biology tools. The DBMS design ...

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Biological weapons are among the most serious threats facing the United States defense forces, today. Currently available bioaerosol sampling systems and cassettes require both sample preparation and a well equipped laboratory for analysis. Other detection methods rely on fragile bio-molecules for recognition of the target analyte. These systems are not suitable for onsite analysis. Infrared spec ...

While zero-based tolerance protective clothing is suitable for first responders, it provides an unnecessary level of protection for first receivers who are exposed to a considerably reduced threat. The use of zero-based tolerance garments by first receivers is particularly problematic since they often work in the same garments for an extended period of time. Consequently, the unique needs of fir ...

The overall objective of this Phase II proposal is to determine the advantages of imidazenil over diazepam or midazolam as a potential anticonvulsant agent for the prophylaxis and for the emergency treatment of organophosphate nerve agent exposure. Therefore, we will compare the dose-dependent efficacy and anticonvulsant tolerance liability of imidazenil or midazolam for protecting rats against di ...

The U.S. Army Medical Research Acquisition Activity at Fort Detrick, MD awarded an SBIR Phase I contract to Rapid Pathogen Screening, Inc. (RPS) in May 2006. The overall objective of this SBIR topic is to develop a lightweight field-portable (i.e., hand-held) device that fulfills a two-fold purpose as follows: (1) it will detect/identify Chemical Warfare Nerve Agents (CWNAs) of operational conce ...