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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A High Throughput Screening Approach Enabling Sustainable Discovery of Novel Lead Compounds from Natural Product Extracts

    SBC: CFD Research Corporation            Topic: A07T034

    We propose the development of a high-throughput screening platform to facilitate the discovery of lead compounds from natural product extracts (NPEs). The proposed effort encompasses (a) utilization of NPEs from novel sources (cave organisms) with rich chemical diversity, (b) development of assays for specifically identified malaria targets, and (c) development of data management and analysis tool ...

    STTR Phase I 2007 Department of DefenseArmy
  2. A High Throughput Screening Approach Enabling Sustainable Discovery of Novel Lead Compounds from Natural Product Extracts

    SBC: CFD Research Corporation            Topic: A07T034

    Emerging drug resistance in infectious threats poses a health risk for deployed forces. The primary objective of the Phase I effort was to enable the development of a sustainable drug discovery effort to continually generate lead compounds for discovery and derivative synthesis. Successful completion of Phase I demonstrated the utilization of a novel source of lead compounds, validation of two hi ...

    STTR Phase II 2008 Department of DefenseArmy
  3. A Microfluidic System for Affinity Reagent Generation and Assay Development for High-Throughput Biomarker Validation

    SBC: CFD Research Corporation            Topic: A07147

    Protein biomarkers are finding increasing application in Force Health Protection and health surveillance. However, very few biomarkers have been verified and validated. This deficiency has been ascribed primarily to availability of reagents (affinity probes). There is a need for assays to measure biomarker candidates, which must be accompanied by the development of reagents for detection. We propo ...

    SBIR Phase I 2007 Department of DefenseArmy
  4. A Systems Biology Approach to Enable Safe Administration of Mefloquine

    SBC: CFD Research Corporation            Topic: A06T034

    Mefloquine is known to cause adverse neurological effects, possibly attributable to single nucleotide polymorphisms (SNPs). Our objective is to develop a genetic screen capable of determining the susceptibility of an individual to Mefloquine neurotoxicity. In Phase I, transcriptional profiling of primary neurons exposed to Mefloquine was used to construct an intracellular pathway model to explain ...

    STTR Phase II 2007 Department of DefenseArmy
  5. Accurate and Reliable Rocket Thruster Technology

    SBC: Analytical Services, Inc.            Topic: A08040

    In this SBIR project, a preliminary design of a highly accurate, highly repeatable impulse thruster will be completed. ASI, together with ATK, proposes to complete the preliminary design in parallel with the development of a comprehensive thruster model in a Monte Carlo environment that will account for every contributor to repeatability in the final product. Using modern uncertainty analysis te ...

    SBIR Phase I 2008 Department of DefenseArmy
  6. Activity Behavior Modeling Toolkit (ABMT) for Non-Traditional OPFOR (Opposing Forces)

    SBC: RADIANCE TECHNOLOGIES, INC.            Topic: A07112

    The objective of this effort, proposed by Radiance Technologies, Inc. and Science Applications International Corporation (SAIC), is to investigate and design new behavioral models, methodologies, and techniques to identify unique behavior signatures of non-traditional transnational Opposing Forces (OPFOR) and or individuals in the Operations Other Than War (OOTW) environment to assist in predicti ...

    SBIR Phase I 2007 Department of DefenseArmy
  7. Advanced Ferroelectric Materials for Explosive Pulsed Power for Missiles and Munitions

    SBC: TRITEC SYSTEMS, INC.            Topic: A08138

    Polarized-Cast Saturated Polymer (PCSP) FEG working bodies will use state-of-art ferroelectric materials such as PZT 95/5 to demonstrate their first order device characteristics. During this effort, a demonstration of this new ferroelectric material’s performance will be quantified using explosive testing. The goal is to develop a highly producible ferroelectric material with high surface char ...

    SBIR Phase I 2008 Department of DefenseArmy
  8. Advanced Nano-Particle Fuel Gel Formulations for Tactical Bipropulsion Systems

    SBC: CFD Research Corporation            Topic: A07027

    CFD Research Corporation (CFDRC) in conjunction with the New Jersey Institute of Technology (NJIT) propose to develop a fuel gel based on the Army’s most current tertiary amine MMH replacement fuel. We will develop a novel technology for the production of nanoparticles by employing the supercritical antisolvent (SAS) process. With the use of our proprietary software technology that allows us to ...

    SBIR Phase I 2007 Department of DefenseArmy
  9. Automated Knowledge Structuring of Medical Charts Data

    SBC: TEKSOUTH CORPORATION            Topic: OSD08H07

    The Personal and Group Healthcare Portfolio Concept represents a revolutionary shift in thinking about the architecture and solutions design for the next generation of Healthcare Management and Bio-Informatics systems. This proposal is dedicated upon the proposition that the only architectural approach that can accommodate the level of complexity likely to be associated with tomorrow’s healthcar ...

    SBIR Phase I 2008 Department of DefenseArmy
  10. Cheap Miniaturized Intelligent Wireless Missile Sensor Platform

    SBC: Lewis Innovative Technologies, Inc.            Topic: A07026

    The proposed solution is to leverage LIT’s experience in designing and fielding military hardware and sensor-related technologies and teaming with Texas Instruments, a major manufacturer of related technologies, to develop a soundly engineered miniature intelligent wireless missile sensor platform by utilizing an evolving approach to size reduction and power management. Key areas to be address ...

    SBIR Phase I 2007 Department of DefenseArmy

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