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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A High Throughput Screening Approach Enabling Sustainable Discovery of Novel Lead Compounds from Natural Product Extracts

    SBC: CFD Research Corporation            Topic: A07T034

    We propose the development of a high-throughput screening platform to facilitate the discovery of lead compounds from natural product extracts (NPEs). The proposed effort encompasses (a) utilization of NPEs from novel sources (cave organisms) with rich chemical diversity, (b) development of assays for specifically identified malaria targets, and (c) development of data management and analysis tool ...

    STTR Phase I 2007 Department of DefenseArmy
  2. A High Throughput Screening Approach Enabling Sustainable Discovery of Novel Lead Compounds from Natural Product Extracts

    SBC: CFD Research Corporation            Topic: A07T034

    Emerging drug resistance in infectious threats poses a health risk for deployed forces. The primary objective of the Phase I effort was to enable the development of a sustainable drug discovery effort to continually generate lead compounds for discovery and derivative synthesis. Successful completion of Phase I demonstrated the utilization of a novel source of lead compounds, validation of two hi ...

    STTR Phase II 2008 Department of DefenseArmy
  3. A Low-Cost Portable Rehabilitation Device with Intelligent Control to Stretch Spastic Joints

    SBC: Rehabtek LLC            Topic: N/A

    Develops a low-cost and portable rehabilitation device with intelligent control to stretch spastic joints safely and repeatedly througout the range of motion to reduce spasticity/contracture and increase functional performance

    SBIR Phase I 2007 Department of Education
  4. A Low-Cost Portable/Wearable Device for Intelligent Stretching and Movement Training Hypertonic Forearm in Stroke with Outcome Evaluation

    SBC: Rehabtek LLC            Topic: N/A

    This project develops a wearable/portable robotic device, IntelliStretch, to perform therapeuticrehabilitation of the arm with the following three integrated steps: (1) stretching a spastic/stiff jointto its extreme position under intelligent control to loosen the stiff joint, (2) voluntary movement training using virtual reality games interfaced with assistance/resistance control when needed, and ...

    SBIR Phase II 2008 Department of Education
  5. A Microfluidic System for Affinity Reagent Generation and Assay Development for High-Throughput Biomarker Validation

    SBC: CFD Research Corporation            Topic: A07147

    Protein biomarkers are finding increasing application in Force Health Protection and health surveillance. However, very few biomarkers have been verified and validated. This deficiency has been ascribed primarily to availability of reagents (affinity probes). There is a need for assays to measure biomarker candidates, which must be accompanied by the development of reagents for detection. We propo ...

    SBIR Phase I 2007 Department of DefenseArmy
  6. A Standards-Based Tool for Pharmacovigilance

    SBC: LOGOBOTS LLC            Topic: OSD05H08

    Clinical trial data is insufficient for drug safety purposes since not enough patients are covered. Hence the drug design process can be improved if post-marketed safety data can be used to augment data available from clinical trials. The FDA and WHO are some agencies that make such safety data available for pharmacovigilance purposes. The DoD aims to create a data warehouse that combines such pub ...

    SBIR Phase II 2007 Department of DefenseArmy
  7. A Systems Biology Approach to Enable Safe Administration of Mefloquine

    SBC: CFD Research Corporation            Topic: A06T034

    Mefloquine is known to cause adverse neurological effects, possibly attributable to single nucleotide polymorphisms (SNPs). Our objective is to develop a genetic screen capable of determining the susceptibility of an individual to Mefloquine neurotoxicity. In Phase I, transcriptional profiling of primary neurons exposed to Mefloquine was used to construct an intracellular pathway model to explain ...

    STTR Phase II 2007 Department of DefenseArmy
  8. Accurate and Reliable Rocket Thruster Technology

    SBC: Analytical Services, Inc.            Topic: A08040

    In this SBIR project, a preliminary design of a highly accurate, highly repeatable impulse thruster will be completed. ASI, together with ATK, proposes to complete the preliminary design in parallel with the development of a comprehensive thruster model in a Monte Carlo environment that will account for every contributor to repeatability in the final product. Using modern uncertainty analysis te ...

    SBIR Phase I 2008 Department of DefenseArmy
  9. Activity Behavior Modeling Toolkit (ABMT) for Non-Traditional OPFOR (Opposing Forces)

    SBC: RADIANCE TECHNOLOGIES, INC.            Topic: A07112

    The objective of this effort, proposed by Radiance Technologies, Inc. and Science Applications International Corporation (SAIC), is to investigate and design new behavioral models, methodologies, and techniques to identify unique behavior signatures of non-traditional transnational Opposing Forces (OPFOR) and or individuals in the Operations Other Than War (OOTW) environment to assist in predicti ...

    SBIR Phase I 2007 Department of DefenseArmy
  10. Advanced Ferroelectric Materials for Explosive Pulsed Power for Missiles and Munitions

    SBC: TRITEC SYSTEMS, INC.            Topic: A08138

    Polarized-Cast Saturated Polymer (PCSP) FEG working bodies will use state-of-art ferroelectric materials such as PZT 95/5 to demonstrate their first order device characteristics. During this effort, a demonstration of this new ferroelectric material’s performance will be quantified using explosive testing. The goal is to develop a highly producible ferroelectric material with high surface char ...

    SBIR Phase I 2008 Department of DefenseArmy

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