Award Data

Increases in amount and diversity of high-throughput data presents tremendous organizational and analysis challenges to researchers. Our objective in this effort is to address these challenges by designing and implementing a database management system (cipherDB) for the storage, management, analysis, and visualization of diverse biological data types. The Phase I design and implementation of ciphe ...

The DoD Chemical, Biological, Radiological, and Nuclear Defense Program Performance Plan discusses the status of sensing technologies and long-term goals, and shows point biological detection systems are expected to provide 20% of the objective capabilities in FY15. This indicates that there is the need for a man-portable, disposable, rapidly responding biological agent point detector that is capa ...

The overall objective of this Phase II proposal is to determine the advantages of imidazenil over diazepam or midazolam as a potential anticonvulsant agent for the prophylaxis and for the emergency treatment of organophosphate nerve agent exposure. Therefore, we will compare the dose-dependent efficacy and anticonvulsant tolerance liability of imidazenil or midazolam for protecting rats against di ...

This project develops a wearable/portable robotic device, IntelliStretch, to perform therapeuticrehabilitation of the arm with the following three integrated steps: (1) stretching a spastic/stiff jointto its extreme position under intelligent control to loosen the stiff joint, (2) voluntary movement training using virtual reality games interfaced with assistance/resistance control when needed, and ...

For ultra high speed applications in DoD satellite systems, devices and circuits fabricated from III–V semiconductor compounds offer significant advantages over silicon-based technology in terms of operating speed and power. However, the uncertainty in single-event-effect (SEE) response of compound technologies forces the use of empirically-based hardening techniques with penalties in increased ...

The DoD Chemical, Biological, Radiological, and Nuclear Defense Program Performance Plan discusses the status of sensing technologies and long-term goals, and shows point biological detection systems are expected to provide 20% of the objective capabilities in FY15. This indicates that there is the need for a man-portable, disposable, rapidly responding biological agent point detector that is cap ...

The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

The primary objective of this effort is to design and develop a database management system (DBMS) and enable the integrated interpretation of the vast amounts of genomic and proteomic data in proper biological context. This DBMS will enable the development of diagnostic assays for human exposure to specific biological threat agents using an existing suite of systems biology tools. The DBMS design ...

Develops a low-cost and portable rehabilitation device with intelligent control to stretch spastic joints safely and repeatedly througout the range of motion to reduce spasticity/contracture and increase functional performance