Award Data

Increases in amount and diversity of high-throughput data presents tremendous organizational and analysis challenges to researchers. Our objective in this effort is to address these challenges by designing and implementing a database management system (cipherDB) for the storage, management, analysis, and visualization of diverse biological data types. The Phase I design and implementation of ciphe ...

This Phase II SBIR proposal is for the development of a miniaturized real-time visible/UV spectrometer prototype based on micro-opto-electro-mechanical systems (MOEMS) technology. Use of MOEMS technology enables orders of magnitude reductions in size, we

Efficient aerosol collectors are needed to help detect very low concentrations of lethal pathogens, such as Anthrax bacilli, in air. Although existing wetted wall cyclone aerosol collectors can remove a substantial fraction of particulates from a large vo

The overall objective of this Phase II proposal is to determine the advantages of imidazenil over diazepam or midazolam as a potential anticonvulsant agent for the prophylaxis and for the emergency treatment of organophosphate nerve agent exposure. Therefore, we will compare the dose-dependent efficacy and anticonvulsant tolerance liability of imidazenil or midazolam for protecting rats against di ...

This project develops a wearable/portable robotic device, IntelliStretch, to perform therapeuticrehabilitation of the arm with the following three integrated steps: (1) stretching a spastic/stiff jointto its extreme position under intelligent control to loosen the stiff joint, (2) voluntary movement training using virtual reality games interfaced with assistance/resistance control when needed, and ...

Current disaster/crisis management systems are extremely rudimentary, often consisting of little more than an unorganized, hand stapled booklet containing barely pertinent information. MusePlayTM software under development by HyperGalaxy, Inc. provides an intuitive, interactive, highly visual digital content delivery environment which can serve as the perfect platform for next generation disaster ...

The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

The primary objective of this effort is to design and develop a database management system (DBMS) and enable the integrated interpretation of the vast amounts of genomic and proteomic data in proper biological context. This DBMS will enable the development of diagnostic assays for human exposure to specific biological threat agents using an existing suite of systems biology tools. The DBMS design ...

Develops a low-cost and portable rehabilitation device with intelligent control to stretch spastic joints safely and repeatedly througout the range of motion to reduce spasticity/contracture and increase functional performance

THE LONG TERM OBJECTIVE OF THIS PROJECT IS TO PROVIDE AN INTERACTIVE TRAINING SYSTEM FOR NONSPEAKING CHILDREN AND ADULTS. THE COMPUTER-DRIVEN SYSTEM CAN BE CONCEPTUALIZED AS A FLEXIBLE HARDWARE CONFIGURATION WHICH CAN BE PERSONALIZED FOR EACH CHILD'S INPUT/OUTPUT NEEDS AND WHICH "OPENS THE DOOR" TO EXISTING ASSISTIVE TECHNOLOGIES. A MENU-DRIVEN SHELL, CONTROLLED BY THE CHILD OR CLINICIAN, WILL ALL ...