Award Data

Increases in amount and diversity of high-throughput data presents tremendous organizational and analysis challenges to researchers. Our objective in this effort is to address these challenges by designing and implementing a database management system (cipherDB) for the storage, management, analysis, and visualization of diverse biological data types. The Phase I design and implementation of ciphe ...

We hypothesize that the application of the broad-spectrum immune-stimulatory and -modulatory HyperAcute alphaGal Adjuvant Technology will enhance the potency and effectiveness of VEEV vaccine candidates. To complement the exciting preclinical and clinical results obtained with alphaGal-modified anti-cancer vaccines, and preclinical studies with both Ebolavirus and Influenza virus, we will apply th ...

While computers in the classroom provide possibilities for project-based and highly collaborative learning, there is a lack of activities that engage teachers and students in hands-on science learning. The goal of this approach is to provide teachers with the necessary support for inquiry-based learning by utilizing sensors through a multimedia web-based application, OASIS (Online Application to ...

The overall objective of this Phase II proposal is to determine the advantages of imidazenil over diazepam or midazolam as a potential anticonvulsant agent for the prophylaxis and for the emergency treatment of organophosphate nerve agent exposure. Therefore, we will compare the dose-dependent efficacy and anticonvulsant tolerance liability of imidazenil or midazolam for protecting rats against di ...

This project develops a wearable/portable robotic device, IntelliStretch, to perform therapeuticrehabilitation of the arm with the following three integrated steps: (1) stretching a spastic/stiff jointto its extreme position under intelligent control to loosen the stiff joint, (2) voluntary movement training using virtual reality games interfaced with assistance/resistance control when needed, and ...

This Phase I SBIR proposal presents the Torch Technologies approach for the development of advanced, innovative, robust real-time algorithms for the integration of passive and active electro-optical sensor detections and identification information. In our proposal, we detail our ideas regarding the optimal fusion of Chemical Warfare (CW) agent sensor data within the innovative data fusion archite ...

While computers in the classroom provide possibilities for project-based and highly collaborative learning, there is a lack of activities that engage teachers and students in hands-on science learning. The goal of this approach is to provide teachers with the necessary support for inquiry-based learning by utilizing sensors through a multimedia web-based application, OASIS (Online Application to ...

The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

The primary objective of this effort is to design and develop a database management system (DBMS) and enable the integrated interpretation of the vast amounts of genomic and proteomic data in proper biological context. This DBMS will enable the development of diagnostic assays for human exposure to specific biological threat agents using an existing suite of systems biology tools. The DBMS design ...

Our objective is to develop a novel micropower source, microsensor, and communication chip for integration with an insect, thereby delivering a state-of-the-art unmanned chemical detection device. The proposed biological fuel cell (Bio-FC) will leverage ongoing research at CFDRC and provide a compact/lightweight power supply, for mounting on numerous types of insects and producing necessary power ...