Award Data

The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

The primary objective of this effort is to design and develop a database management system (DBMS) and enable the integrated interpretation of the vast amounts of genomic and proteomic data in proper biological context. This DBMS will enable the development of diagnostic assays for human exposure to specific biological threat agents using an existing suite of systems biology tools. The DBMS design ...

Increases in amount and diversity of high-throughput data presents tremendous organizational and analysis challenges to researchers. Our objective in this effort is to address these challenges by designing and implementing a database management system (cipherDB) for the storage, management, analysis, and visualization of diverse biological data types. The Phase I design and implementation of ciphe ...

With global terrorism on the rise, there is an increasing need to develop self sanitizing surfaces and surface treatments with maximum potential to kill biological organisms in order to minimize hazard to human health. Luna Innovations proposes the creation of self sanitizing films that can be used as protective overcoats to destroy bacterial quickly and prevent human infection without the need fo ...

A major obstacle to non-invasive treatment of brain injury and disease is the blood-brain barrier (BBB), which prevents many intravenously injected therapeutics from being taken into the brain. In this program, Luna Innovations and Virginia Tech propose to develop a novel liposome-based delivery system capable of delivering any of a variety of neuroprotective agents of use against organophosphate ...

Carbon based filtration technologies have several known modes of degradation and failure including adsorption of chemical contaminants, adsorption of environmental pollutants and operational interferents, repeated moisture condensation, and moisture vapor adsorption. In unknown hazardous environments, the ultimate End-of-Service-Life Indicator (ESLI)/Residual Life Indicator (RLI) for critical Ind ...

Generic residual life indicator technology developed under PI effort will be matured through reduction of COTS items used in the breadboard design to a miniaturized brassboard system capable of detecting agent saturation front migration through a sorbent. The capability of this brassboard system to detect representative agents from several classes will be demonstrated along with the ability to pr ...

The overall objective of this Phase II proposal is to determine the advantages of imidazenil over diazepam or midazolam as a potential anticonvulsant agent for the prophylaxis and for the emergency treatment of organophosphate nerve agent exposure. Therefore, we will compare the dose-dependent efficacy and anticonvulsant tolerance liability of imidazenil or midazolam for protecting rats against di ...

In this Phase I SBIR project we propose a new imaging mechanism for sub-wavelength THz spectroscopy based on a very strong enhancement of electromagnetic field of the THz radiation at the edges of periodic semiconductor structure. Our recent theoretical study showed THz radiation power enhancement ~1100 with the half power width around the slot edges ~500 nm. Such strongly enhanced local electroma ...

In the Phase I CBD SBIR project, Vibratess proposed and confirmed a new imaging mechanism for subwavelength THz spectroscopy based on very strong enhancement of electromagnetic field of THz radiation at the edges of periodic semiconductor structure. The technology to fabricate an integrated miniature detector assembly (with a Schottky diode, a circuit and a nano-size antenna to probe radiation tr ...