Award Data

In this Phase I SBIR project TA&T will use ceramic stereolithography to fabricate integrally cored shells for investment cast turbine airfoils with the goals of demonstrating dimensional accuracy specifications can be met and demonstrating castability of a legacy airfoil. The application target will be advanced high pressure turbine (HPT) airfoils cast in single crystal superalloys, the most diffi ...

Big Delta Systems (BDS) is commercializing an advanced, additive manufacturing technology for the production of superior Li-ion battery electrodes that push the performance envelope of todays batteries while significantly reducing costs. This additive manufacturing technology offers an unprecedented design freedom for battery manufacturers to micro-engineer the structure of electrodes optimized fo ...

The overall objective of the proposed project is to develop new injury criteria, model based risk assessment methodology, and a software tool to assess neck injury risk from head supported mass (HSM) loading. Based on the foundation of Phase I feasibility studies, the proposed Phase II work will focus on model enhancement, extension and validation, risk assessment, and software integration and tes ...

Platelets play a central role in hemostasis and are responsible for many inherited and acquired bleeding disorders and thrombic events in human beings. A significant portion of post-trauma deaths are related to coagulopathy or hemorrhage events for both injured soldiers and civilian patients. Several platelet function analyzers have been designed and developed; however due to form-factor and/or ...

Timely management and closure of burn wounds are critical for proper emergency care and the assurance of positive outcomes for the warfighter. Current technologies rely on reagents that cannot respond effectively to the different classes of pathogens that

Current methods for stem cell isolation are time-consuming, costly, and labor-intensive, and ill-suited for point of care applications. To overcome these limitations, we propose to develop and demonstrate a high-throughput, non-invasive, microfluidic stem cell analyzer to enable a rapid isolation of high-quality stem cell products from clinically relevant samples. Our technology enables significan ...

Many emergency cricothyrotomy kits have been developed in an attempt to simplify this potentially life-saving medical procedure. However, none of the existing kits perform noticeably better than the standard surgical kit. The standard kit itself has led

Drug transport in the central nervous system is highly regulated by the Blood-Brain Barrier (BBB). Most medicines, including many for treating cancer, Alzheimer’s, and stroke, do not meet essential criteria, such as lipophilicity and low molecular weight, required for appreciable transport into the brain. However, endogenous peptides, such as insulin or transferrin, and certain monoclonal anti ...

Burkholderia pseudomallei and Burkholderia mallei are highly pathogenic Gram - negative bacteria and the causative agents of melioidosis and glanders, respectively. These infections, which occur in humans and other animals, are endemic is wide regions of the developing world. This Phase II SBIR project will build on the success of our Phase I work, which established methods for generating monoclon ...

Aerosols represent one of the more efficient methods to distribute biological and chemical agents throughout the atmosphere. Small aerosol droplets can be readily inhaled and easily penetrate deep into the lungs where they lodge in bronchial alveoli. Within the alveoli, chemical and biological agents can breach epithelial and endothelial cell layers and enter the bloodstream, where they cause da ...