Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Oligonucleotide Enzyme Surrogate (OnES)

    SBC: Accacia International LLC            Topic: CBD08108

    Historically organophosphorus compounds such as insecticides and nerve agents have been susceptible to decomposition by proteinaceous enzymes. Organophosphate hydrolases (OPH) represent a practical method to deactivate such compounds peripherally and on surfaces. However, when such organophosphates are ingested, the use of proteinaceous enzymes such as OPH can be problematic because of their tende ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  2. Carbon Nanotube-Based Filters for Aerosol Sample Collection

    SBC: AGAVE BIOSYSTEMS INC.            Topic: CBD07111

    Aerosols represent one of the more efficient methods to distribute biological and chemical agents throughout the atmosphere. Small aerosol droplets can be readily inhaled and easily penetrate deep into the lungs where they lodge in bronchial alveoli. Within the alveoli, chemical and biological agents can breach epithelial and endothelial cell layers and enter the bloodstream, where they cause da ...

    SBIR Phase I 2007 Department of DefenseOffice for Chemical and Biological Defense
  3. Ribozymes for In Vivo Degradation of G-Nerve Agents

    SBC: AGAVE BIOSYSTEMS INC.            Topic: CBD08108

    Given the possibility to administer prophylactic doses of protein bioscavengers inactivating OP nerve agents before they reach their acetylcholinesterase target, much attention has been given to proteins such as human butyrylcholinesterase and paraoxonase I. As small nucleic acid catalysts can exhibit triphosphoesterase activities, the identification of new molecules active against nerve agents w ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  4. Collective Protection for Military Working Dogs

    SBC: AGAVE BIOSYSTEMS INC.            Topic: CBD08103

    Shelter enclosures for military working dogs in the event of a CB attack is a technology gap identified by the Joint Requirements Office. Important parameters to consider in the design of protective enclosures include low weight and size to minimize transport requirements; rapid setup; and accommodation of canine physiological and psychological comfort needs. The overall operational weight of th ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  5. Multiple Indication Adjuvants

    SBC: BIOPROTECTION SYSTEMS CORP.            Topic: CBD08105

    The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  6. Development of a Database Management System to Enable Rapid, Efficient Assay Design for Use in Detection and Diagnosis of Human Exposure to Biological

    SBC: CFD Research Corporation            Topic: CBD07114

    The primary objective of this effort is to design and develop a database management system (DBMS) and enable the integrated interpretation of the vast amounts of genomic and proteomic data in proper biological context. This DBMS will enable the development of diagnostic assays for human exposure to specific biological threat agents using an existing suite of systems biology tools. The DBMS design ...

    SBIR Phase I 2007 Department of DefenseOffice for Chemical and Biological Defense
  7. Omni-Directional, Wind and Water Tolerant Inlet for the DFU

    SBC: ENERTECHNIX, INC.            Topic: CBD07116

    In the proposed project, Enertechnix will develop optimized designs for an improved inlet for the Dry Filter Unit (DFU) capable of achieving high collection efficiencies for particles between 1 and 20 microns in diameter while functioning reliably on board naval vessels. This new inlet will be insensitive to wind direction and speed and will be tolerant of harsh weather and wave conditions. By inc ...

    SBIR Phase I 2007 Department of DefenseOffice for Chemical and Biological Defense
  8. Blood Brain Barrier (BBB) Permeable Encapsulating Agents for Effective Delivery of CNS-active Agents

    SBC: Lynntech Inc.            Topic: CBD08107

    Drug transport in the central nervous system is highly regulated by the Blood-Brain Barrier (BBB). Most medicines, including many for treating cancer, Alzheimer’s, and stroke, do not meet essential criteria, such as lipophilicity and low molecular weight, required for appreciable transport into the brain. However, endogenous peptides, such as insulin or transferrin, and certain monoclonal anti ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  9. Sequential Isoelectric Point Separation of Proteins Using Non-Gel, Microfluidic System

    SBC: Lynntech Inc.            Topic: CBD08101

    The measurement of biochemical changes within the human body can provide a means to monitor a person’s physiological health. Many of the biochemicals that provide a snapshot of a person’s health are proteins. The challenge with measuring proteins is the existence of approximately ten orders of magnitude difference in concentration between the most abundant proteins in blood and those typically ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  10. Dynamic Multicomponent Optical Analyzer for Chemical Weapon (CW) Exposure Studies

    SBC: SCIENCE & ENGINEERING SERVICES, INC.            Topic: CBD08104

    We propose to build a compact laser photoacoustic spectrometric (LPAS) sensor for continuous, real-time broadband analysis of multiple chemical components, and perform field tests to qualify it for dynamic monitoring of chemical warfare agents (CWA). Our sensor will be based on our laboratory LPAS instrument (at technology readiness level TRL-4) that has already demonstrated successful multicompon ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
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