Award Data

Historically organophosphorus compounds such as insecticides and nerve agents have been susceptible to decomposition by proteinaceous enzymes. Organophosphate hydrolases (OPH) represent a practical method to deactivate such compounds peripherally and on surfaces. However, when such organophosphates are ingested, the use of proteinaceous enzymes such as OPH can be problematic because of their tende ...

This proposal presents a Phase II SBIR project to produce prototypes of the automated high precision, low disperse rate powder disseminator for the US Army, that has been successfully designed and analyzed in the Phase I project. In the development of the sensitive detecting agent, we need to release a precise amount of C&B agents in the controlled detection experiments. At the end of this Phase ...

Aerosols represent one of the more efficient methods to distribute biological and chemical agents throughout the atmosphere. Small aerosol droplets can be readily inhaled and easily penetrate deep into the lungs where they lodge in bronchial alveoli. Within the alveoli, chemical and biological agents can breach epithelial and endothelial cell layers and enter the bloodstream, where they cause da ...

Given the possibility to administer prophylactic doses of protein bioscavengers inactivating OP nerve agents before they reach their acetylcholinesterase target, much attention has been given to proteins such as human butyrylcholinesterase and paraoxonase I. As small nucleic acid catalysts can exhibit triphosphoesterase activities, the identification of new molecules active against nerve agents w ...

Shelter enclosures for military working dogs in the event of a CB attack is a technology gap identified by the Joint Requirements Office. Important parameters to consider in the design of protective enclosures include low weight and size to minimize transport requirements; rapid setup; and accommodation of canine physiological and psychological comfort needs. The overall operational weight of th ...

Imaging sensors are a crucial component of modern defense. The ideal sensor has acute visual sensing capabilities and communicates instantly when threats are identified. It should also have night vision capabilities and cover a broadband spectral range including near ultraviolet and infrared. A robotic broadband night vision camera is highly desirable. Such a robotic broadband low-light-level came ...

Many DOD systems require advanced digital signal processing and image processing functions that cannot be efficiently implemented on conventional micro-processors, hence designers have started mapping these applications onto FPGAs. However, most FPGA implementations are manually designed and highly coupled to the hardware, often taking advantage of special hardware features of the target FPGA. T ...

The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

Chlorine gas was first used as a weapon during World War I and has reemerged as a threat in Iraq compounding the dangers from existing improvised explosive devices. One of the significant challenges with preventing attacks that involve toxic industrial chemicals (TICs) like chlorine, ammonia is that they have genuine civilian uses for water treatment, in refrigeration systems, and others, that m ...

The primary objective of this effort is to design and develop a database management system (DBMS) and enable the integrated interpretation of the vast amounts of genomic and proteomic data in proper biological context. This DBMS will enable the development of diagnostic assays for human exposure to specific biological threat agents using an existing suite of systems biology tools. The DBMS design ...