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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Oligonucleotide Enzyme Surrogate (OnES)

    SBC: Accacia International LLC            Topic: CBD08108

    Historically organophosphorus compounds such as insecticides and nerve agents have been susceptible to decomposition by proteinaceous enzymes. Organophosphate hydrolases (OPH) represent a practical method to deactivate such compounds peripherally and on surfaces. However, when such organophosphates are ingested, the use of proteinaceous enzymes such as OPH can be problematic because of their tende ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  2. SBIR PHASE I, TOPIC 239 HIGH-THROUGHPUT SELECTION OF APTAMERS AGAINST CANCER BIOM

    SBC: Accacia International LLC            Topic: N/A

    N/A

    SBIR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  3. T7 RNA polymerase engineering and RNA amplification

    SBC: Accacia International LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Expanding use of microarray systems for global gene expression profiling is leading biological research, providing diagnostic and prognostic value to physicians and facilitating target discovery during drug and vaccine development. There is strong interest in extending this microarray capability to more RNA-limited material to the point that a single cell can b ...

    STTR Phase II 2007 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a Lightweight, Durable, Adjustable Composite Backrest

    SBC: ACCESSIBLE DESIGNS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): We have designed a prototype lightweight, sturdy, user adjustable ergonomically designed backrest support for ultralight weight wheelchairs that will provide necessary postural support and provide a variety of positions to ease dressing, propulsion, and seated comfort. The backrest will improve user comfort, function, and posture during multiple activities of ...

    SBIR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  5. Novel Targeted Therapy for Breast Cancer

    SBC: A&G PHARMACEUTICAL, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Breast cancer remains one of the top three cancers to affect and cause mortality in women. Major shortcomings with current treatment are the high level of side effects and insufficient efficacy, particularly for patients with metastatic disease. Targeted cancer therapy is designed to treat only the cancer cells and minimize damage to healthy cells. These target ...

    SBIR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  6. Profiling EGFR and Her2 in Breast Cancer using Multiplex Tissue Immunostaining

    SBC: 20 20 Genesystems Inc            Topic: N/A

    DESCRIPTION (provided by applicant): We propose to develop a novel method and kit for profiling the expression and activation of signal transduction proteins in breast tumors. The goal is to create new "companion" diagnostics to better select patients likely to respond to targeted therapies, including Herceptin(r) and novel tyrosine kinase inhibitors. 20/20 will utilize its proprietary layered pep ...

    SBIR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  7. Peptide Array for Profiling of Autoantibodies in Non-small Cell Lung Cancer

    SBC: 20 20 Genesystems Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Approximately 135,000 new cases of non-small cell lung cancer (NSCLC) are diagnosed each year in the USA, yet only 20%-25% of those patients will be diagnosed at a sufficiently early stage to be cured by surgical or other procedures. When used in concert with radiographic imaging, a sensitive and specific blood test for NSCLC could be a clinically valuable and ...

    SBIR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  8. Profiling ER, PR, EGFR and HER2 in Breast Cancer Using Multiplex Tissue Immusta

    SBC: 20 20 Genesystems Inc            Topic: N/A

    DESCRIPTION (provided by applicant): We propose to develop a novel method and kit for profiling the expression and activation of signal transduction proteins in breast tumors. The goal is to create new companion diagnostics to better select patients like ly to respond to targeted therapies, including Herceptin. and novel tyrosine kinase inhibitors. 20/20 will utilize its proprietary Layered Expr ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  9. Inhaled nisin as an emergency intervention against antibiotic sensitive or resist

    SBC: AFG BIOSOLUTIONS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The deliberate release of Bacillus anthracis spores remains an imminent threat both in terms of bioterrorism and biowarfare. Individuals who inhale these spores are at extreme risk of infection and death from anthrax. C urrent prophylaxis and therapy in the event of B. anthracis spore inhalation fall into two categories. Vaccination to protect against future ex ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  10. Carbon Nanotube-Based Filters for Aerosol Sample Collection

    SBC: AGAVE BIOSYSTEMS INC.            Topic: CBD07111

    Aerosols represent one of the more efficient methods to distribute biological and chemical agents throughout the atmosphere. Small aerosol droplets can be readily inhaled and easily penetrate deep into the lungs where they lodge in bronchial alveoli. Within the alveoli, chemical and biological agents can breach epithelial and endothelial cell layers and enter the bloodstream, where they cause da ...

    SBIR Phase I 2007 Department of DefenseOffice for Chemical and Biological Defense
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