Award Data

Historically organophosphorus compounds such as insecticides and nerve agents have been susceptible to decomposition by proteinaceous enzymes. Organophosphate hydrolases (OPH) represent a practical method to deactivate such compounds peripherally and on surfaces. However, when such organophosphates are ingested, the use of proteinaceous enzymes such as OPH can be problematic because of their tende ...

The aims and opportunities of Photo-Automatic-Linking for 3-D Facial-Imaging System(PALS-3D) are focused on innovative development, iterative evolving, and near-term fielding of modular inexpensive imaging systems that enable users to capture a person’s face in three dimensions(3-D) and identify the individual based on two dimensions(2-D) and/or 3-D baseline imagery using lightweight, low power, ...

Aerosols represent one of the more efficient methods to distribute biological and chemical agents throughout the atmosphere. Small aerosol droplets can be readily inhaled and easily penetrate deep into the lungs where they lodge in bronchial alveoli. Within the alveoli, chemical and biological agents can breach epithelial and endothelial cell layers and enter the bloodstream, where they cause da ...

Given the possibility to administer prophylactic doses of protein bioscavengers inactivating OP nerve agents before they reach their acetylcholinesterase target, much attention has been given to proteins such as human butyrylcholinesterase and paraoxonase I. As small nucleic acid catalysts can exhibit triphosphoesterase activities, the identification of new molecules active against nerve agents w ...

Shelter enclosures for military working dogs in the event of a CB attack is a technology gap identified by the Joint Requirements Office. Important parameters to consider in the design of protective enclosures include low weight and size to minimize transport requirements; rapid setup; and accommodation of canine physiological and psychological comfort needs. The overall operational weight of th ...

The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

The DoD Chemical, Biological, Radiological, and Nuclear Defense Program Performance Plan discusses the status of sensing technologies and long-term goals, and shows point biological detection systems are expected to provide 20% of the objective capabilities in FY15. This indicates that there is the need for a man-portable, disposable, rapidly responding biological agent point detector that is cap ...

The DoD Chemical, Biological, Radiological, and Nuclear Defense Program Performance Plan discusses the status of sensing technologies and long-term goals, and shows point biological detection systems are expected to provide 20% of the objective capabilities in FY15. This indicates that there is the need for a man-portable, disposable, rapidly responding biological agent point detector that is capa ...

Military ground mobility vehicles often operate in areas of high heat with no environmental conditioning systems for cooling the individual soldier or critical vehicle electronic systems. Typical vehicle climate control systems are large refrigerant-based systems that are not man portable. SOCOM expressed a desire for cooling equipment that is man portable for short periods of time (~3 hours) du ...

The primary objective of this effort is to design and develop a database management system (DBMS) and enable the integrated interpretation of the vast amounts of genomic and proteomic data in proper biological context. This DBMS will enable the development of diagnostic assays for human exposure to specific biological threat agents using an existing suite of systems biology tools. The DBMS design ...