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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Novel Microfludic Device for Drug Toxicity Studies

    SBC: CFD Research Corporation            Topic: CBD10103

    Current drug discovery and development efforts are severely limited by expensive animal trials and oversimplified in vitro models. Results obtained from in vitro models are not predictive of in vivo toxicity owing to significant difference from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device that reproduces the physiological ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  2. Deployed First Responder Course of Action (COA) Evaluation and After Action Review (AAR) Tools

    SBC: AEGIS TECHNOLOGIES GROUP, INC., THE            Topic: OSD10H07

    Many geospatial technologies and modeling techniques exist, especially for 3-D visualization of correlated layers of data. A gap remains in integrating the unstructured world of voice, chat, and free-form text communications to the more structured world

    SBIR Phase I 2011 Department of DefenseDefense Health Program
  3. Development of a Database Management System to Enable Rapid, Efficient Assay Design for Use in Detection and Diagnosis of Human Exposure to Biological

    SBC: CFD Research Corporation            Topic: CBD07114

    The primary objective of this effort is to design and develop a database management system (DBMS) and enable the integrated interpretation of the vast amounts of genomic and proteomic data in proper biological context. This DBMS will enable the development of diagnostic assays for human exposure to specific biological threat agents using an existing suite of systems biology tools. The DBMS design ...

    SBIR Phase I 2007 Department of DefenseOffice for Chemical and Biological Defense
  4. Development of a Database Management System to Enable Rapid, Efficient Assay Design for Use in Detection and Diagnosis of Human Exposure to Biological

    SBC: CFD Research Corporation            Topic: CBD07114

    Increases in amount and diversity of high-throughput data presents tremendous organizational and analysis challenges to researchers. Our objective in this effort is to address these challenges by designing and implementing a database management system (cipherDB) for the storage, management, analysis, and visualization of diverse biological data types. The Phase I design and implementation of ciphe ...

    SBIR Phase II 2008 Department of DefenseOffice for Chemical and Biological Defense
  5. Focal Plane Array Technology for Passive Hyperspectral Standoff Detection

    SBC: EPIR TECHNOLOGIES INC            Topic: CBD10105

    Chemical imaging sensors require focal plane arrays (FPAs) incorporating long wavelength infrared (LWIR) detectors suitable for hyperspectral detection. These detectors require high sensitivity to account for the low photon counts in narrow wavelength bands. The required sensitivity elevates the associated costs, so a need exists for a lower cost LWIR FPA for use with chemical imaging sensors. The ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  6. Imidazenil: A Protective Agent Against Chemical Warfare Agents induced Status Epilepticus

    SBC: NEUPHARMA, INC.            Topic: CBD05116

    The overall objective of this Phase II proposal is to determine the advantages of imidazenil over diazepam or midazolam as a potential anticonvulsant agent for the prophylaxis and for the emergency treatment of organophosphate nerve agent exposure. Therefore, we will compare the dose-dependent efficacy and anticonvulsant tolerance liability of imidazenil or midazolam for protecting rats against di ...

    SBIR Phase II 2007 Department of DefenseOffice for Chemical and Biological Defense
  7. Microfluidic High-throughput Platform for Determining Kinetic Constants of Enzyme Variants

    SBC: CFD Research Corporation            Topic: CBD10107

    Current high-throughput platforms rely on labeled substrates that produce detectable spectroscopic signals upon reaction for monitoring enzyme catalytic activity. Add to that the high price tag for these instruments, ranging from several hundred thousand to millions of dollars, and there is a clear need for alternate solutions for a label-free, low-cost, high-throughput enzyme screening platform. ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  8. Multiple Indication Adjuvants

    SBC: BIOPROTECTION SYSTEMS CORP.            Topic: CBD08105

    The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  9. Novel Methods to Monitor Health Status and Clinical Laboratory Data: Portable Acquisition, Assessment, and Reporting

    SBC: Mimosa Acoustics Inc.            Topic: OSD09H26

    Mimosa Acoustics will develop a portable binaural audiological device, based on our successful HearID system. HearID is a clinical system for otoacoustic emission and middle-ear power analysis testing; it is FDA and CE-marked. The new system will have the ability to conduct a variety of audiological tests especially for use in hearing-conservation programs, including: flexible otoacoustic emission ...

    SBIR Phase II 2011 Department of DefenseDefense Health Program

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