Award Data

Historically organophosphorus compounds such as insecticides and nerve agents have been susceptible to decomposition by proteinaceous enzymes. Organophosphate hydrolases (OPH) represent a practical method to deactivate such compounds peripherally and on surfaces. However, when such organophosphates are ingested, the use of proteinaceous enzymes such as OPH can be problematic because of their tende ...

Aerosols represent one of the more efficient methods to distribute biological and chemical agents throughout the atmosphere. Small aerosol droplets can be readily inhaled and easily penetrate deep into the lungs where they lodge in bronchial alveoli. Within the alveoli, chemical and biological agents can breach epithelial and endothelial cell layers and enter the bloodstream, where they cause da ...

Given the possibility to administer prophylactic doses of protein bioscavengers inactivating OP nerve agents before they reach their acetylcholinesterase target, much attention has been given to proteins such as human butyrylcholinesterase and paraoxonase I. As small nucleic acid catalysts can exhibit triphosphoesterase activities, the identification of new molecules active against nerve agents w ...

Shelter enclosures for military working dogs in the event of a CB attack is a technology gap identified by the Joint Requirements Office. Important parameters to consider in the design of protective enclosures include low weight and size to minimize transport requirements; rapid setup; and accommodation of canine physiological and psychological comfort needs. The overall operational weight of th ...

In Phase I of this SBIR we have taken several significant steps in the development of a Cyber Assets in the Battlefield Network (CABN) system by identifying military and commercial use cases, developing and getting feedback on a variety of notional visual display mock-ups, and identifying commercial and military transition targets. Our first commercial market will be the wireless (WiFi) security a ...

ClotFoam is a novel crosslinked polymer designed to stop hemorrhage without compression in severe wounds outside the operating room. ClotFoam’s ability to promote hemostasis in cases severe bleeding is based on the physical and coagulation properties of a fibrin sealant embedded in a gelatin support and enhanced by procoagulants, ions and molecules that increase the affinity to collagen. It is ...

Battlefield injuries are unique in terms of severity, types, and combinations. The ability to develop therapeutics designed to treat a broad spectrum of battle injuries is a unique opportunity with significant positive benefits. In particular, increased capillary permeability/leak and ischemia-reperfusion injuries play a significant role in military injuries such as battlefield trauma, hemorrhagi ...

The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

Recent DoD programs have furthered intelligence, surveillance and reconnaissance (ISR) objectives by advancing the state-of-the-art in sensor resource management and target tracking. The majority of this work, however, has focused upon the problem of tracking a handful of high value targets for lengthy periods. There is a need to develop systems that detect anomalous activities that have the po ...

Black River Systems Co., Inc. proposes to perform radar system operational and performance trades for detecting slow moving and crossing targets in dense clutter, and to establish the analytic basis of a new innovative technique, Spatial-Temporal Differential Analysis (STDA). Comparisons of radar architecture candidates and cost/benefit analysis of these architectures will be accomplished with th ...