Award Data

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...

Rapid and accurate characterization and/or identification of the differentiation state of the stem cells is critical to the development of regenerative medicine technologies as well as tissue engineering solutions. Current methods and devices are time-consuming, labor-intensive, costly, invasive, and consequently, ill-suited for deployment in military and other limited resource settings. To overco ...

To properly measure (and understand) the performance of a standoff detector, properties of the challenge cloud must be known. Meteorological models, such as HPAC and VLSTRACK, have proven to be reasonably good tools for predicting cloud properties. However, a problem with these tools is that they deliver ensemble averages and may not describe a specific cloud to the detail required. The Dugway ...

The primary objective of this effort is to design and develop a database management system (DBMS) and enable the integrated interpretation of the vast amounts of genomic and proteomic data in proper biological context. This DBMS will enable the development of diagnostic assays for human exposure to specific biological threat agents using an existing suite of systems biology tools. The DBMS design ...

Increases in amount and diversity of high-throughput data presents tremendous organizational and analysis challenges to researchers. Our objective in this effort is to address these challenges by designing and implementing a database management system (cipherDB) for the storage, management, analysis, and visualization of diverse biological data types. The Phase I design and implementation of ciphe ...

Injuries to soft tissues in extremities represent a high percentage of battlefield wounds in recent conflicts. Therapies for restoring function to injured muscle are needed for Wounded Warriors suffering from debilitating and sometimes disfiguring musculoskeletal injuries. Regenerative medicine holds promises of new treatment strategies, yet there remains significant need to develop better platfo ...

Effective collective protection fabrics must have a reliable closure system. During our Phase I Work Plan, Sigma-K began developing a Hermetic Textile Closure Hardware (HATCH) system. The HATCH combines both a magnetic and geometric self locking mechanism that will provide a hermetic seal when closed. Our current Phase I successes include developing self closing samples that can provide a hermetic ...

Many studies exist which validate M & S based medical training tools as effective in improving practitioner performance. There is little research addressing the cost effectiveness of such training solutions. A gap exists in the integration of cost, performance, schedule, risk, patient outcome improvement, and training efficiency and training transfer factors in assessing medical M & S based train ...

The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

Skeletal muscle injury is a significant challenge to warfighters due to the severity of the injuries often caused by Improvised Explosive Devices. Currently, there are few viable clinical treatment options for these types of injuries. Keratin hydrogels offer a solution to these challenges as carriers of cells and growth factors. Human epithelial keratins are the major structural proteins in cel ...