Award Data

Platelets play a central role in hemostasis and are responsible for many inherited and acquired bleeding disorders and thrombic events in human beings. A significant portion of post-trauma deaths are related to coagulopathy or hemorrhage events for both injured soldiers and civilian patients. Several platelet function analyzers have been designed and developed; however due to form-factor and/or ...

Timely management and closure of burn wounds are critical for proper emergency care and the assurance of positive outcomes for the warfighter. Current technologies rely on reagents that cannot respond effectively to the different classes of pathogens that

Drug transport in the central nervous system is highly regulated by the Blood-Brain Barrier (BBB). Most medicines, including many for treating cancer, Alzheimer’s, and stroke, do not meet essential criteria, such as lipophilicity and low molecular weight, required for appreciable transport into the brain. However, endogenous peptides, such as insulin or transferrin, and certain monoclonal anti ...

Burkholderia pseudomallei and Burkholderia mallei are highly pathogenic Gram - negative bacteria and the causative agents of melioidosis and glanders, respectively. These infections, which occur in humans and other animals, are endemic is wide regions of the developing world. This Phase II SBIR project will build on the success of our Phase I work, which established methods for generating monoclon ...

Aerosols represent one of the more efficient methods to distribute biological and chemical agents throughout the atmosphere. Small aerosol droplets can be readily inhaled and easily penetrate deep into the lungs where they lodge in bronchial alveoli. Within the alveoli, chemical and biological agents can breach epithelial and endothelial cell layers and enter the bloodstream, where they cause da ...

Shelter enclosures for military working dogs in the event of a CB attack is a technology gap identified by the Joint Requirements Office. Important parameters to consider in the design of protective enclosures include low weight and size to minimize transport requirements; rapid setup; and accommodation of canine physiological and psychological comfort needs. The overall operational weight of th ...

KBSI proposes to design and develop a Data Integration and Predictive Analysis System (IPAS) for the prediction of incidents of human infectious diseases. IPAS will utilize innovative collection of data from open data sources, veterinary and medical professionals, and public observations, together with data cleaning, harmonization, spatio-temporal pattern extraction, factor analysis, and predicti ...

In this Phase I program, Fabrico Technology, Professor Leonid Bunegin of the University of Texas Health Science Center at San Antonio (UTHSC-SA), and Dr. Rocco Armonda, Director, Neuroendovascular Surgery and Neurotrauma, MedStar-Georgetown University Hos

The overall objective of this Phase II proposal is to determine the advantages of imidazenil over diazepam or midazolam as a potential anticonvulsant agent for the prophylaxis and for the emergency treatment of organophosphate nerve agent exposure. Therefore, we will compare the dose-dependent efficacy and anticonvulsant tolerance liability of imidazenil or midazolam for protecting rats against di ...

About 40% of trauma-related deaths are related to rapid onset of coagulopathy and the vast majority of trauma patients are coagulopathic at the time of death. Lynntech proposes to develop a novel, easy-to-use and cost effective device for simultaneous quantitative real-time detection of multiple proteins involved in the hemostatic mechanism, using human unprocessed whole blood as the input sample. ...