Award Data

Historically organophosphorus compounds such as insecticides and nerve agents have been susceptible to decomposition by proteinaceous enzymes. Organophosphate hydrolases (OPH) represent a practical method to deactivate such compounds peripherally and on surfaces. However, when such organophosphates are ingested, the use of proteinaceous enzymes such as OPH can be problematic because of their tende ...

This Small Business Technology Transfer Phase I project research seeks to change the paradigm that chemical reactions need mechanical mixing. Innovative Fiber Reactors (FR) offer a 100X change in efficiency of chemical and biochemical manufacturing while eliminating dispersions. This research focuses on biodiesel transesterification and esterification reactions. Biodiesel plants convert fats/oils ...

The Small Business Innovation Research (SBIR) Phase I project will develop a novel Omni-Directional Antireflective Coating (Omni-AR) to improve light collection in photovoltaic cells. The coating consists of a monolayer of microscale silica particles partially immersed into a film of spin-on glass. Its antireflection is broad spectrum and less dependent on sunlight incident angle, thus omni-direct ...

Given the possibility to administer prophylactic doses of protein bioscavengers inactivating OP nerve agents before they reach their acetylcholinesterase target, much attention has been given to proteins such as human butyrylcholinesterase and paraoxonase I. As small nucleic acid catalysts can exhibit triphosphoesterase activities, the identification of new molecules active against nerve agents w ...

Shelter enclosures for military working dogs in the event of a CB attack is a technology gap identified by the Joint Requirements Office. Important parameters to consider in the design of protective enclosures include low weight and size to minimize transport requirements; rapid setup; and accommodation of canine physiological and psychological comfort needs. The overall operational weight of th ...

This Small Business Innovation Research (SBIR) Phase I This Small Business Technology Transfer (STTR) Phase I project is aimed at developing a multi-objective bi-level approach to highway alignment optimization. Unlike the rapid developments in the automobile and construction industries road design is still carried out in the traditional manner which is more than 50 years old. The increasing highw ...

This Small Business Technology Transfer Phase I research develops a novel bioprocess platform for the synthesis of toxic enzymes as inactive pro-enzymes in bacteria that can subsequently be activated via simple pH and/or temperature shifts. Recombinant enzymes for industrial synthetic applications or pharmacologic replacement therapies can be very difficult and expensive to produce in large quanti ...

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This Small Business Innovation Research Phase I project is for the development of technology to crystallize proteins using less sample and with higher speed and success than current high throughput protein crystallization methods. Protein crystallization is an intermediate step in determining the precise three-dimensional shape of a protein, and proteins are involved in virtually every cellular pr ...