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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Oligonucleotide Enzyme Surrogate (OnES)

    SBC: Accacia International LLC            Topic: CBD08108

    Historically organophosphorus compounds such as insecticides and nerve agents have been susceptible to decomposition by proteinaceous enzymes. Organophosphate hydrolases (OPH) represent a practical method to deactivate such compounds peripherally and on surfaces. However, when such organophosphates are ingested, the use of proteinaceous enzymes such as OPH can be problematic because of their tende ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  2. Ribozymes for In Vivo Degradation of G-Nerve Agents

    SBC: AGAVE BIOSYSTEMS INC.            Topic: CBD08108

    Given the possibility to administer prophylactic doses of protein bioscavengers inactivating OP nerve agents before they reach their acetylcholinesterase target, much attention has been given to proteins such as human butyrylcholinesterase and paraoxonase I. As small nucleic acid catalysts can exhibit triphosphoesterase activities, the identification of new molecules active against nerve agents w ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  3. Collective Protection for Military Working Dogs

    SBC: AGAVE BIOSYSTEMS INC.            Topic: CBD08103

    Shelter enclosures for military working dogs in the event of a CB attack is a technology gap identified by the Joint Requirements Office. Important parameters to consider in the design of protective enclosures include low weight and size to minimize transport requirements; rapid setup; and accommodation of canine physiological and psychological comfort needs. The overall operational weight of th ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  4. Multiple Indication Adjuvants

    SBC: BIOPROTECTION SYSTEMS CORP.            Topic: CBD08105

    The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  5. Blood Brain Barrier (BBB) Permeable Encapsulating Agents for Effective Delivery of CNS-active Agents

    SBC: LYNNTECH INC.            Topic: CBD08107

    Drug transport in the central nervous system is highly regulated by the Blood-Brain Barrier (BBB). Most medicines, including many for treating cancer, Alzheimer’s, and stroke, do not meet essential criteria, such as lipophilicity and low molecular weight, required for appreciable transport into the brain. However, endogenous peptides, such as insulin or transferrin, and certain monoclonal anti ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  6. Sequential Isoelectric Point Separation of Proteins Using Non-Gel, Microfluidic System

    SBC: LYNNTECH INC.            Topic: CBD08101

    The measurement of biochemical changes within the human body can provide a means to monitor a person’s physiological health. Many of the biochemicals that provide a snapshot of a person’s health are proteins. The challenge with measuring proteins is the existence of approximately ten orders of magnitude difference in concentration between the most abundant proteins in blood and those typically ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  7. Hand-Held Raman Analyzer for Chemical Identification

    SBC: REAL-TIME ANALYZERS INC            Topic: CBD08102

    The overall goal of this proposed program (through Phase III) is to build a hand-held Raman analyzer that can perform non-contact identification of chemicals in the field. This will be accomplished by modifying a commercially available FT-Raman analyzer to employ 976 or 1064 nm laser excitation. Feasibility will be demonstrated in Phase I by comparing the ability of three Raman systems using las ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  8. Dynamic Multicomponent Optical Analyzer for Chemical Weapon (CW) Exposure Studies

    SBC: SCIENCE & ENGINEERING SERVICES, INC.            Topic: CBD08104

    We propose to build a compact laser photoacoustic spectrometric (LPAS) sensor for continuous, real-time broadband analysis of multiple chemical components, and perform field tests to qualify it for dynamic monitoring of chemical warfare agents (CWA). Our sensor will be based on our laboratory LPAS instrument (at technology readiness level TRL-4) that has already demonstrated successful multicompon ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  9. Hands-Free Kinetic System for Medical Simulation

    SBC: Intelligent Automation, Inc.            Topic: OSD10H06

    In recent years, many human-computer interaction and virtual environment systems have incorporated haptic devices. However, the range of environment properties and types of interactions enabled by existing haptic interfaces are very limited. Haptic feedba

    SBIR Phase I 2011 Department of DefenseDefense Health Agency
  10. Deployed First Responder Course of Action (COA) Evaluation and After Action Review (AAR) Tools

    SBC: Aegis Technologies Group, LLC, The            Topic: OSD10H07

    Many geospatial technologies and modeling techniques exist, especially for 3-D visualization of correlated layers of data. A gap remains in integrating the unstructured world of voice, chat, and free-form text communications to the more structured world

    SBIR Phase I 2011 Department of DefenseDefense Health Agency
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