Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Oligonucleotide Enzyme Surrogate (OnES)

    SBC: Accacia International LLC            Topic: CBD08108

    Historically organophosphorus compounds such as insecticides and nerve agents have been susceptible to decomposition by proteinaceous enzymes. Organophosphate hydrolases (OPH) represent a practical method to deactivate such compounds peripherally and on surfaces. However, when such organophosphates are ingested, the use of proteinaceous enzymes such as OPH can be problematic because of their tende ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  2. Ribozymes for In Vivo Degradation of G-Nerve Agents

    SBC: AGAVE BIOSYSTEMS INC.            Topic: CBD08108

    Given the possibility to administer prophylactic doses of protein bioscavengers inactivating OP nerve agents before they reach their acetylcholinesterase target, much attention has been given to proteins such as human butyrylcholinesterase and paraoxonase I. As small nucleic acid catalysts can exhibit triphosphoesterase activities, the identification of new molecules active against nerve agents w ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  3. Collective Protection for Military Working Dogs

    SBC: AGAVE BIOSYSTEMS INC.            Topic: CBD08103

    Shelter enclosures for military working dogs in the event of a CB attack is a technology gap identified by the Joint Requirements Office. Important parameters to consider in the design of protective enclosures include low weight and size to minimize transport requirements; rapid setup; and accommodation of canine physiological and psychological comfort needs. The overall operational weight of th ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  4. Multiple Indication Adjuvants

    SBC: BIOPROTECTION SYSTEMS CORP.            Topic: CBD08105

    The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  5. Blood Brain Barrier (BBB) Permeable Encapsulating Agents for Effective Delivery of CNS-active Agents

    SBC: Lynntech Inc.            Topic: CBD08107

    Drug transport in the central nervous system is highly regulated by the Blood-Brain Barrier (BBB). Most medicines, including many for treating cancer, Alzheimer’s, and stroke, do not meet essential criteria, such as lipophilicity and low molecular weight, required for appreciable transport into the brain. However, endogenous peptides, such as insulin or transferrin, and certain monoclonal anti ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  6. Sequential Isoelectric Point Separation of Proteins Using Non-Gel, Microfluidic System

    SBC: Lynntech Inc.            Topic: CBD08101

    The measurement of biochemical changes within the human body can provide a means to monitor a person’s physiological health. Many of the biochemicals that provide a snapshot of a person’s health are proteins. The challenge with measuring proteins is the existence of approximately ten orders of magnitude difference in concentration between the most abundant proteins in blood and those typically ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  7. Dynamic Multicomponent Optical Analyzer for Chemical Weapon (CW) Exposure Studies

    SBC: SCIENCE & ENGINEERING SERVICES, INC.            Topic: CBD08104

    We propose to build a compact laser photoacoustic spectrometric (LPAS) sensor for continuous, real-time broadband analysis of multiple chemical components, and perform field tests to qualify it for dynamic monitoring of chemical warfare agents (CWA). Our sensor will be based on our laboratory LPAS instrument (at technology readiness level TRL-4) that has already demonstrated successful multicompon ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  8. Software for Design and Validation of DNA Nanostructure Surface Patterning

    SBC: Celadon Laboratories, Inc.            Topic: CBD12103

    A continuing threat to U.S. military personnel and civilians is exposure to toxic chemicals and pathogens. While there exist methods and systems for vaccine development, agent detection, and assessment of exposure and immune response, it remains imperative to investigate next-generation technologies that have the potential to improve by an order of magnitude their cost, sensitivity, specificity, a ...

    SBIR Phase I 2012 Department of DefenseOffice for Chemical and Biological Defense
  9. A Novel Diagnostic Assay for the Detection of Mycobacterium Tuberculosis

    SBC: Lynntech Inc.            Topic: OSD11H05

    One in three humans currently living on earth are infected with Mycobacterium tuberculosis, the bacterium that causes tuberculosis. This number is astonishing and underscores our ever-increasing need for accurate and efficient tuberculosis diagnostics. This is especially true for the US military wherein troops are serving in areas around the world that have high tuberculosis incidence rates. While ...

    SBIR Phase I 2012 Department of DefenseDefense Health Program
  10. The PACeR Gold- Multiplex Pathogen Identification Platform for Detection of Mycobacterium Tuberculosis Infections.

    SBC: Accacia International LLC            Topic: OSD11H05

    The World Health Organization estimates that more than one-third of the worldwide population is infected with Mycobacterium tuberculosis (MTB), the causative agent of most cases of tuberculosis (TB). Patients who are infected with MTB, but do not have active TB disease have latent tuberculosis infection (LTBI), a non-communicable, asymptomatic condition which might develop into active TB disease m ...

    SBIR Phase I 2012 Department of DefenseDefense Health Program
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