Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Oligonucleotide Enzyme Surrogate (OnES)

    SBC: Accacia International LLC            Topic: CBD08108

    Historically organophosphorus compounds such as insecticides and nerve agents have been susceptible to decomposition by proteinaceous enzymes. Organophosphate hydrolases (OPH) represent a practical method to deactivate such compounds peripherally and on surfaces. However, when such organophosphates are ingested, the use of proteinaceous enzymes such as OPH can be problematic because of their tende ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  2. Ribozymes for In Vivo Degradation of G-Nerve Agents

    SBC: AGAVE BIOSYSTEMS INC.            Topic: CBD08108

    Given the possibility to administer prophylactic doses of protein bioscavengers inactivating OP nerve agents before they reach their acetylcholinesterase target, much attention has been given to proteins such as human butyrylcholinesterase and paraoxonase I. As small nucleic acid catalysts can exhibit triphosphoesterase activities, the identification of new molecules active against nerve agents w ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  3. Collective Protection for Military Working Dogs

    SBC: AGAVE BIOSYSTEMS INC.            Topic: CBD08103

    Shelter enclosures for military working dogs in the event of a CB attack is a technology gap identified by the Joint Requirements Office. Important parameters to consider in the design of protective enclosures include low weight and size to minimize transport requirements; rapid setup; and accommodation of canine physiological and psychological comfort needs. The overall operational weight of th ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  4. Multiple Indication Adjuvants

    SBC: BIOPROTECTION SYSTEMS CORP.            Topic: CBD08105

    The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  5. Blood Brain Barrier (BBB) Permeable Encapsulating Agents for Effective Delivery of CNS-active Agents

    SBC: Lynntech Inc.            Topic: CBD08107

    Drug transport in the central nervous system is highly regulated by the Blood-Brain Barrier (BBB). Most medicines, including many for treating cancer, Alzheimer’s, and stroke, do not meet essential criteria, such as lipophilicity and low molecular weight, required for appreciable transport into the brain. However, endogenous peptides, such as insulin or transferrin, and certain monoclonal anti ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  6. Sequential Isoelectric Point Separation of Proteins Using Non-Gel, Microfluidic System

    SBC: Lynntech Inc.            Topic: CBD08101

    The measurement of biochemical changes within the human body can provide a means to monitor a person’s physiological health. Many of the biochemicals that provide a snapshot of a person’s health are proteins. The challenge with measuring proteins is the existence of approximately ten orders of magnitude difference in concentration between the most abundant proteins in blood and those typically ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  7. Dynamic Multicomponent Optical Analyzer for Chemical Weapon (CW) Exposure Studies

    SBC: SCIENCE & ENGINEERING SERVICES, INC.            Topic: CBD08104

    We propose to build a compact laser photoacoustic spectrometric (LPAS) sensor for continuous, real-time broadband analysis of multiple chemical components, and perform field tests to qualify it for dynamic monitoring of chemical warfare agents (CWA). Our sensor will be based on our laboratory LPAS instrument (at technology readiness level TRL-4) that has already demonstrated successful multicompon ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  8. Scene Registration Augmented Reality as an Educational Tool to Identify Underlying Anatomy during Medical Simulation Training

    SBC: SHARP VISION SOFTWARE LLC            Topic: DHP163002

    A scene registration augmented reality proof-of-concept for medical education is proposed with the goal of making medical education, especially anatomical learning, intuitive, effective, accurate, and productive by leveraging the latest augmented reality technologies. To achieve the goal, following aspects will be investigated and developed: 1) recognize the fiducial markers on a mannequin or on a ...

    SBIR Phase I 2017 Department of DefenseDefense Health Program
  9. Delivery System for Cryopreserved Eukaryotic Cell Vaccines

    SBC: SANARIA INC.            Topic: DHP163003

    Sanaria has designed a cryovial for cryopreserving eukaryotic cells that can be used for distribution of cryopreserved eukaryotic cell-based vaccines and is suitable for direct vaccine administration to patients. The cryovials can be stored in liquid nitrogen vapor phase (LNVP) and are currently undergoing testing for suitability as the FDA-registered container for Sanarias Plasmodium falciparum ( ...

    SBIR Phase I 2017 Department of DefenseDefense Health Program
  10. Noninvasive Monitor of Vascular Volume Fluid Shifts

    SBC: INNOVITAL SYSTEMS, INC.            Topic: DHA17007

    Accurate intravascular volume assessment improves the detection of hemorrhage and hypovolemia and facilitates decision-making relative to resuscitation, surgery and selection of higher level of medical care. Non-invasive assessment techniques are particularly important in the field. Current approaches and devices do not have broad utility and availability. The phonocardiogram, acquired and inte ...

    SBIR Phase I 2017 Department of DefenseDefense Health Program
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