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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Oligonucleotide Enzyme Surrogate (OnES)
SBC: Accacia International LLC Topic: CBD08108Historically organophosphorus compounds such as insecticides and nerve agents have been susceptible to decomposition by proteinaceous enzymes. Organophosphate hydrolases (OPH) represent a practical method to deactivate such compounds peripherally and on surfaces. However, when such organophosphates are ingested, the use of proteinaceous enzymes such as OPH can be problematic because of their tende ...
SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense -
Ribozymes for In Vivo Degradation of G-Nerve Agents
SBC: AGAVE BIOSYSTEMS INC. Topic: CBD08108Given the possibility to administer prophylactic doses of protein bioscavengers inactivating OP nerve agents before they reach their acetylcholinesterase target, much attention has been given to proteins such as human butyrylcholinesterase and paraoxonase I. As small nucleic acid catalysts can exhibit triphosphoesterase activities, the identification of new molecules active against nerve agents w ...
SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense -
Collective Protection for Military Working Dogs
SBC: AGAVE BIOSYSTEMS INC. Topic: CBD08103Shelter enclosures for military working dogs in the event of a CB attack is a technology gap identified by the Joint Requirements Office. Important parameters to consider in the design of protective enclosures include low weight and size to minimize transport requirements; rapid setup; and accommodation of canine physiological and psychological comfort needs. The overall operational weight of th ...
SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense -
Multiple Indication Adjuvants
SBC: BIOPROTECTION SYSTEMS CORP. Topic: CBD08105The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...
SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense -
Blood Brain Barrier (BBB) Permeable Encapsulating Agents for Effective Delivery of CNS-active Agents
SBC: LYNNTECH INC. Topic: CBD08107Drug transport in the central nervous system is highly regulated by the Blood-Brain Barrier (BBB). Most medicines, including many for treating cancer, Alzheimer’s, and stroke, do not meet essential criteria, such as lipophilicity and low molecular weight, required for appreciable transport into the brain. However, endogenous peptides, such as insulin or transferrin, and certain monoclonal anti ...
SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense -
Sequential Isoelectric Point Separation of Proteins Using Non-Gel, Microfluidic System
SBC: LYNNTECH INC. Topic: CBD08101The measurement of biochemical changes within the human body can provide a means to monitor a person’s physiological health. Many of the biochemicals that provide a snapshot of a person’s health are proteins. The challenge with measuring proteins is the existence of approximately ten orders of magnitude difference in concentration between the most abundant proteins in blood and those typically ...
SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense -
Dynamic Multicomponent Optical Analyzer for Chemical Weapon (CW) Exposure Studies
SBC: SCIENCE & ENGINEERING SERVICES, INC. Topic: CBD08104We propose to build a compact laser photoacoustic spectrometric (LPAS) sensor for continuous, real-time broadband analysis of multiple chemical components, and perform field tests to qualify it for dynamic monitoring of chemical warfare agents (CWA). Our sensor will be based on our laboratory LPAS instrument (at technology readiness level TRL-4) that has already demonstrated successful multicompon ...
SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense -
Exploiting Natural Products-Based Therapeutics for Aflatoxin Mitigation
SBC: CFD RESEARCH CORPORATION Topic: CBD152003Aflatoxins are a paradigm among fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk forthe development of hepatocellular carcinoma. Currently, there are no known countermeasures that can selectively mitigate aflatoxin toxicity andthe available options are only symptomatic treatments. To meet this challenge, we propose to harness the microbio ...
SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense -
Fully Integrated Light Therapy-Based Wound Dressings for Wound Healing Applications
SBC: LYNNTECH INC. Topic: DHP15B002Between Operation Iraqi Freedom, Operation Enduring Freedom, and Operation New Dawn, the total number of U.S. Casualties (those Wounded in Action) has exceeded 52,000 as of January 30, 2015. These numbers point to the fact that active warfighters in the battlefield are almost constantly exposed to the threat of external penetrating wounds. The goal of combat wound care is to protect open wounds u ...
SBIR Phase I 2016 Department of DefenseDefense Health Agency -
High Fidelity Computational Models for Aggregated Tissue Interaction in Surgical Simulations
SBC: CFD RESEARCH CORPORATION Topic: DHP16A001Surgical simulations aiming to support surgeon practices and medical education have attracted enormous research effort over the last two decades. However, the physical reality, especially on simulating aggregated tissue interaction, is still unsatisfactory. In this proposed work, an open source surgery simulation framework, SoFMIS, will be utilized and enhanced with tissue interaction models to a ...
STTR Phase I 2016 Department of DefenseDefense Health Agency