Award Data

DESCRIPTION (provided by applicant): Propionibacterium acnes (P. acnes) is most notably recognized for its role in acne vulgaris, the most common skin disease, affecting 85-100% of the population at some point in their lives. Current treatments for vulgari s acne using isotretinoin (13-cis-retinoic acid) or antibiotics can have many undesirable effects, including depression, teratogenicity, hormon ...

DESCRIPTION (provided by applicant): Alzheimer disease (AD) is the most common neurodegenerative disease in the elderly. To date, no satisfactory treatment is available for AD. One of the pathological hallmarks of AD is deposits of amyloid protein (Aa) in neuritic plaques and cerebral vessels. Increasing lines of evidence support the notion that Aa and its precursor (APP) play pathogenetic roles i ...

DESCRIPTION (provided by applicant): Cell Cures' technology utilizes easily isolated and well characterized adult human skeletal muscle stem cells (satellite cells or myoblasts). These striated muscle progenitor cells provide an expandable source of proliferating cells which have already been utilized in numerous clinical trials. While the injection of the proliferating myoblasts has proven clinic ...

DESCRIPTION (provided by applicant): EpiVax discovers and develops epitqpe-driven vaccines by screening microbial genomes for protective epitopes. In this application, we describe a genome-based approach for the development of a therapeutic vaccine against Helicobacter pylori disease. First, the H. pylori genome will be scanned for immunodominant Th epitopes by computer-driven (EpiMatrix) analysi ...

Description: (Provided by Applicant) Sepsis a serious life-threatening condition resulting from a harmful inflammatory reaction of the body due to bacterial infection. The mortality rate of sepsis remains high in intensive care units around the world but therapeutic interventions have been largely unsuccessful. Clearly, there is a great need for inventing efficacious therapeutic drugs to treat pat ...

DESCRIPTION (provided by applicant): Conditionally replicative adenovirus vectors (CRAds) are novel vectors with utility as virotherapy agents for alternative cancer therapies. These vectors already have established a broad safety record in humans. However, two confounding problems limit efficacy of these drug candidates, the paucity of the native Ad receptor on tumor tissues, and host humoral res ...

DESCRIPTION (provided by applicant): One of the main challenges in the discovery of intracellular biomarkers and identification of therapeutic targets is the lack of a mechanistic understanding of the complex underlying pathways. The tremendous increase in both the quantity and diversity of cellular data represents a significant challenge to researchers seeking to construct biologically relevant ...

DESCRIPTION (provided by applicant): Male-to-female intimate partner violence accounts for 26% of violence-related injuries in women presenting in hospital emergency departments and 30% of all female homicides. Early to mid-adolescence provides an excellen t window of opportunity for the prevention of intimate partner violence. Patterns of relating in intimate relationships are still relatively ...

DESCRIPTION (provided by applicant): Plasma fractionation is one of the largest industry segments in global therapeutic protein manufacture. The United States plays an important role in this industry since it represents the largest plasma collection and manufacturing base that accounts for more than 50% of the world supply of plasma. Even though more than 22 million liters of plasma are collected ...

Not avaiable.