Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. A novel therapy for sepsis

    SBC: BIOPOWERTECH            Topic: N/A

    Description: (Provided by Applicant) Sepsis a serious life-threatening condition resulting from a harmful inflammatory reaction of the body due to bacterial infection. The mortality rate of sepsis remains high in intensive care units around the world but therapeutic interventions have been largely unsuccessful. Clearly, there is a great need for inventing efficacious therapeutic drugs to treat pat ...

    SBIR Phase I 2007 Department of Health and Human Services
  2. A Shielded Conditionally Replicative Adenoviral Vector

    SBC: VECTORLOGICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Conditionally replicative adenovirus vectors (CRAds) are novel vectors with utility as virotherapy agents for alternative cancer therapies. These vectors already have established a broad safety record in humans. However, two confounding problems limit efficacy of these drug candidates, the paucity of the native Ad receptor on tumor tissues, and host humoral res ...

    SBIR Phase I 2007 Department of Health and Human Services
  3. A Simulation Tool to Enable Identification of Critical Network Interactions Using

    SBC: CFD Research Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): One of the main challenges in the discovery of intracellular biomarkers and identification of therapeutic targets is the lack of a mechanistic understanding of the complex underlying pathways. The tremendous increase in both the quantity and diversity of cellular data represents a significant challenge to researchers seeking to construct biologically relevant ...

    SBIR Phase I 2008 Department of Health and Human Services
  4. Acne Vaccines Targeting a Surface Sialidase and a Secreted CAMP Factor Toxin

    SBC: VAXIN INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Propionibacterium acnes (P. acnes) is most notably recognized for its role in acne vulgaris, the most common skin disease, affecting 85-100% of the population at some point in their lives. Current treatments for vulgari s acne using isotretinoin (13-cis-retinoic acid) or antibiotics can have many undesirable effects, including depression, teratogenicity, hormon ...

    STTR Phase I 2008 Department of Health and Human Services
  5. Adenovirus vectored vaccines for Alzheimer's disease

    SBC: VAXIN INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Alzheimer disease (AD) is the most common neurodegenerative disease in the elderly. To date, no satisfactory treatment is available for AD. One of the pathological hallmarks of AD is deposits of amyloid protein (Aa) in neuritic plaques and cerebral vessels. Increasing lines of evidence support the notion that Aa and its precursor (APP) play pathogenetic roles i ...

    STTR Phase I 2007 Department of Health and Human Services
  6. Breath Ammonia and Clinical Aging Research

    SBC: Streamline Automation, LLC            Topic: N/A

    Not avaiable.

    SBIR Phase I 2007 Department of Health and Human Services
  7. Capsid-Incorporated Antigen for Novel Adenovirus Vaccine

    SBC: VECTORLOGICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The recognition that most cancers possess tumor-specific antigens or over-express antigens present in normal tissue, which can be immunogenic, provides the rational for using immunotherapy approaches as treatments for c ancer patients. One such approach is delivery of the tumor-associated antigen (TAA) to the main antigen presentation cells of the immune system ...

    SBIR Phase I 2008 Department of Health and Human Services
  8. Controlled transgenics via 3'UTR and site specificity

    SBC: OPEN BIOSYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term goal of this proposal is to provide a reliable, repeatable, and comparable method for generating mouse transgenics that allows for exquisite control over expression level, genome location, and strain background. The tool set ultimately produced will be a collection of 6 bacterial artificial chromosome (BAC) vectors designed to work in complimen ...

    SBIR Phase I 2005 Department of Health and Human Services
  9. Critical Data Processing for Chemical Warfare Simulant Field Testing- Advanced Data Fusion

    SBC: TORCH TECHNOLOGIES INC            Topic: CBD05110

    To properly measure (and understand) the performance of a standoff detector, properties of the challenge cloud must be known. Meteorological models, such as HPAC and VLSTRACK, have proven to be reasonably good tools for predicting cloud properties. However, a problem with these tools is that they deliver ensemble averages and may not describe a specific cloud to the detail required. The Dugway ...

    SBIR Phase I 2005 Department of DefenseOffice for Chemical and Biological Defense
  10. Delivery system development for a reservoir targeted Lyme disease vaccine

    SBC: FoodSource Lure Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): The incidence and geographic distribution of Lyme disease in the U.S. has increased steadily since its first description in 1977. Efforts to stem the spread of the disease through controlling the population of its tick vector and/or the mouse reservoirs of the disease have met with only limited success. The only approved human vaccine to protect against Lyme d ...

    STTR Phase I 2008 Department of Health and Human Services
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