Award Data

DESCRIPTION (provided by applicant): Propionibacterium acnes (P. acnes) is most notably recognized for its role in acne vulgaris, the most common skin disease, affecting 85-100% of the population at some point in their lives. Current treatments for vulgari s acne using isotretinoin (13-cis-retinoic acid) or antibiotics can have many undesirable effects, including depression, teratogenicity, hormon ...

DESCRIPTION (provided by applicant): This goal of this SBIR project is to quantify the feasibility and potential for an implantable prosthetic device at the distal end of the cut bone for above-knee (AK) amputees. It is hypothesized that such a device can significantly improve residual limb tissue health and load distribution within the prosthetic socket leading to a dramatic improvement in the f ...

DESCRIPTION (provided by applicant): Falls are a leading cause of injury and mortality in the elderly. Ongoing research using the ActiveStep treadmill completed in Phase I/Phase II, has demonstrated that a treadmill-based perturbation tool for tripping and slipping has demonstrated a positive effect on the biomechanical performance of older adults subject to laboratory induced trip and slip distu ...

DESCRIPTION (provided by applicant): Alzheimer disease (AD) is the most common neurodegenerative disease in the elderly. To date, no satisfactory treatment is available for AD. One of the pathological hallmarks of AD is deposits of amyloid protein (Aa) in neuritic plaques and cerebral vessels. Increasing lines of evidence support the notion that Aa and its precursor (APP) play pathogenetic roles i ...

DESCRIPTION (provided by applicant): This goal of this SBIR project is to quantify and validate the feasibility and potential for a non- obtrusive, wearable, in-shoe gait-monitoring device for children with Cerebral Palsy (CP). It is hypothesized that continuous monitoring and analysis of simple gait parameters in children with CP outside the clinical laboratory and during normal daily activities ...

DESCRIPTION (provided by applicant): This goal of this SBIR project is to quantify and validate the feasibility and potential for a non- obtrusive, wearable, in-shoe gait-monitoring device for children with Cerebral Palsy (CP). It is hypothesized that con tinuous monitoring and analysis of simple gait parameters in children with CP outside the clinical laboratory and during normal daily activitie ...

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DESCRIPTION (provided by applicant): The specific aim of this research program is to develop and transition a low-cost, liquid oxygen (LOX) generation system to support ambulatory patients using Home Oxygen Therapy (HOT). Currently in the United States, yearly expenditures on HOT are nearly two billion dollars. These expenditures will increase dramatically over the next 10 years due to the aging ...

Description: (Provided by Applicant) Sepsis a serious life-threatening condition resulting from a harmful inflammatory reaction of the body due to bacterial infection. The mortality rate of sepsis remains high in intensive care units around the world but therapeutic interventions have been largely unsuccessful. Clearly, there is a great need for inventing efficacious therapeutic drugs to treat pat ...

DESCRIPTION (provided by applicant): Conditionally replicative adenovirus vectors (CRAds) are novel vectors with utility as virotherapy agents for alternative cancer therapies. These vectors already have established a broad safety record in humans. However, two confounding problems limit efficacy of these drug candidates, the paucity of the native Ad receptor on tumor tissues, and host humoral res ...