Award Data

The goal of this project is to investigate the feasability of a unique sampling method that will lead to the development of a reagentless infrared (IR) based BW agent detection system. The current JPBDS uses lateral flow immunoassay technology as the final step in detecting bioagents, and has a detection limit of 10^5 spores/ml[ref 1]. Preliminary data from our infrared approach indicates a mini ...

A major obstacle to non-invasive treatment of brain injury and disease is the blood-brain barrier (BBB), which prevents many intravenously injected therapeutics from being taken into the brain. In this program, Luna Innovations and Virginia Tech propose to develop a novel liposome-based delivery system capable of delivering any of a variety of neuroprotective agents of use against organophosphate ...

"In Phase I of this project, an innovative non-specific colorimetric chemisty was developed and fabricated for detecting hydrogen cyanide, cyanogen chloride, hydrogen fluoride, phosgene and s-mustard and nerve agent simulants, simultaneously. Two of thefabricated colorimetric indicators fulfilled the desired requirements in terms of sensitivity and non-specificity of the targeted warfare agents ...

"In Phase I of this project, an innovative non-specific colorimetric chemisty was developed and fabricated for detecting hydrogen cyanide, cyanogen chloride, hydrogen fluoride, phosgene and s-mustard and nerve agent simulants, simultaneously. Two of thefabricated colorimetric indicators fulfilled the desired requirements in terms of sensitivity and non-specificity of the targeted warfare agents ...

To properly measure (and understand) the performance of a standoff detector, properties of the challenge cloud must be known. Meteorological models, such as HPAC and VLSTRACK, have proven to be reasonably good tools for predicting cloud properties. However, a problem with these tools is that they deliver ensemble averages and may not describe a specific cloud to the detail required. The Dugway ...

The primary objective of this effort is to design and develop a database management system (DBMS) and enable the integrated interpretation of the vast amounts of genomic and proteomic data in proper biological context. This DBMS will enable the development of diagnostic assays for human exposure to specific biological threat agents using an existing suite of systems biology tools. The DBMS design ...

Increases in amount and diversity of high-throughput data presents tremendous organizational and analysis challenges to researchers. Our objective in this effort is to address these challenges by designing and implementing a database management system (cipherDB) for the storage, management, analysis, and visualization of diverse biological data types. The Phase I design and implementation of ciphe ...

Carbon based filtration technologies have several known modes of degradation and failure including adsorption of chemical contaminants, adsorption of environmental pollutants and operational interferents, repeated moisture condensation, and moisture vapor adsorption. In unknown hazardous environments, the ultimate End-of-Service-Life Indicator (ESLI)/Residual Life Indicator (RLI) for critical Ind ...

Generic residual life indicator technology developed under PI effort will be matured through reduction of COTS items used in the breadboard design to a miniaturized brassboard system capable of detecting agent saturation front migration through a sorbent. The capability of this brassboard system to detect representative agents from several classes will be demonstrated along with the ability to pr ...

"Sensor Research and Development Corporation (SRD) proposes to develop an Automated Measurement of Breakthrough in Real-time (AMBR) prototype to test chemical protective materials. AMBR will increase the safety, efficiency, and sample throughput for fabrictests while improving data quality and expanding test capabilities. SRD will develop AMBR by integrating proven solid-state chemical agent sen ...