Award Data

Current drug discovery and development programs are severely limited by the expensive animal trials and oversimplified in vitro models. Results obtained from the in vitro models are not predictive of in vivo toxicity owing to significant difference in testing from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device for quantitati ...

The goal of this project is to investigate the feasability of a unique sampling method that will lead to the development of a reagentless infrared (IR) based BW agent detection system. The current JPBDS uses lateral flow immunoassay technology as the final step in detecting bioagents, and has a detection limit of 10^5 spores/ml[ref 1]. Preliminary data from our infrared approach indicates a mini ...

information) During Phase I the Torch Technologies developed, demonstrated, and assessed the feasibility of an innovative, real-time multi-layered CW sensor data fusion network capability supporting advanced standoff detection and early warning against CB threats. Torch merged two significant technologies that we developed for the Department of Defense: 1) the ACRES CW multi-sensor data fusion t ...

To properly measure (and understand) the performance of a standoff detector, properties of the challenge cloud must be known. Meteorological models, such as HPAC and VLSTRACK, have proven to be reasonably good tools for predicting cloud properties. However, a problem with these tools is that they deliver ensemble averages and may not describe a specific cloud to the detail required. The Dugway ...

The primary objective of this effort is to design and develop a database management system (DBMS) and enable the integrated interpretation of the vast amounts of genomic and proteomic data in proper biological context. This DBMS will enable the development of diagnostic assays for human exposure to specific biological threat agents using an existing suite of systems biology tools. The DBMS design ...

Increases in amount and diversity of high-throughput data presents tremendous organizational and analysis challenges to researchers. Our objective in this effort is to address these challenges by designing and implementing a database management system (cipherDB) for the storage, management, analysis, and visualization of diverse biological data types. The Phase I design and implementation of ciphe ...

Complete human anatomy avatars have a broad role in advanced training environments, performance-related physiological modeling, and simulations for the purpose of designing protective armor. The overall goal of this project is to design and develop computer software and data structures for adding articulated joints and natural motions to USARIEMs static finite element avatars and to create a graph ...

GeneCapture, Inc. is proposing to develop a rapid in vitro diagnostic prototype using our patented molecular-based CAPTURE (ConfirmActive Pathogens Through Unamplified RNA Expression) assay. Based on the results and experience gained in our Phase I STTR contractHDTRA1-16C-0061: Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point of Care Applications, we p ...

Molecular biology techniques allow generating combinatorial libraries of large number of enzyme variants. However, there is currently no technology available for screening the enzyme libraries for identifying variants with improved activity for the substrate. We propose to develop a novel, microfluidic, high-throughput platform for determining kinetic constants of enzyme variants and identifying v ...

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens,whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial andalphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable and ...