Award Data

The use of nanoparticles has increased in manufacturing, industry, and commercial products over the past two decades. As a result, governmental agencies, industry, and academia worldwide have formed advisory groups to evaluate exposure and toxicity issues surrounding the potential adverse effects of nanomaterials on human health. However, assessing the potential effects of nanoparticles on human h ...

DESCRIPTION (provided by applicant): The overall aim for this Small Business Innovative Research project is to develop and evaluate a web-based 3D interactive Virtual Emergency Medical Technician-Basic Training Program. ArchieMD's goal is to develop a prod uct that will use 3D interactive visualizations and a virtual patient simulator to teach Emergency Medical Technician (EMT) concepts required f ...

DESCRIPTION (provided by applicant): In order for the nation to remain competitive in the life science industries, the nation must produce an adequate number of students who pursue degrees in life sciences. Recent years have seen a disturbing drop in Unite d States' student interest in pursuing science education and careers. At the same time, demand for science-based degrees is rapidly increasing ...

DESCRIPTION (provided by applicant): This SBIR Phase I project defines and implements a new class of technology-enabled science and environmental health science (EHS) 9-12 teacher support. The proposed innovation is called Teachers iPod or TiP. The goals o f TiP are to: (1) prepare teachers to be more effective, knowledgeable, and professional in their delivery of specific lessons, content, and/or ...

DESCRIPTION (provided by applicant): Liver damage and failure due to various forms of hepatic injury is a significant source of overall morbidity and mortality in the US and worldwide. Persistent hepatic injury occurs during viral hepatitis, fatty liver di sease (steatohepatitis), drug or alcohol and autoimmune induced hepatitis. Clinical conditions are numerous where hepatic injury is a vital com ...

DESCRIPTION (provided by applicant): Human umbilical cord blood is a rich source of hematopoietic stem cells that can be used to re-populate the blood and immune systems. In preliminary studies we have identified a novel population of non-hematopoietic cel ls that exhibit extensive self-renewal and markers characteristic of stem cells. We postulate that these cells can be used to repair the brain ...

DESCRIPTION (provided by applicant): Linomide is a known anti-inflammatory drug. Recently we have synthesized a new analog of Linomide, linomide-5. The objective of this proposal is to develop linomide-5 as a therapeutic for treating diabetic retinopathy ( DR) and age-related macular degeneration (AMD). Together, these diseases constitute the major causes of blindness worldwide. In both cases, ret ...

DESCRIPTION (provided by applicant): The objective of this proposal is to develop a service for the high-throughput drug screening of compounds to treat Age-Related Macular Degeneration (AMD). In our preliminary studies, we have identified a genetically-mo dified mouse (Vldlr-/-) that presents with symptoms nearly identical to AMD pathogenesis in humans. Based on the following observations, we hyp ...

DESCRIPTION (provided by applicant): The objective of this proposal is to examine the efficacy of CLT-005, a novel small molecule inhibitor of Stat3, for treating inflammatory and vascular leakage of the retina of diabetic retinopathy. Retinal blood vesse l formation is known to be mediated by the vascular endothelial growth factor (VEGF) protein, and current FDA approved treatments for AMD are i ...

DESCRIPTION (provided by applicant): The majority of obstetric deliveries in the US undergo continuous electronic uterine activity monitoring. Typically, an external tocodynamometer (strain gauge) is employed to provide the frequency and timing of uterine contractions. The reliability of this monitor depends on its proper positioning (which may be disturbed by patient movement), and the transmiss ...