Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. High Fidelity Modeling of Building Collapse with Realistic Visualization of Resulting Damage and Debris

    SBC: Thornton Tomasetti, Inc.            Topic: DTRA082005

    The proposed Phase II effort investigates innovative finite element formulations, alternative structural modeling procedures and modern parallel computational strategies to improve the computational performance of high fidelity simulation software for modeling the progressive collapse behavior of blast damaged buildings. Its goal is to reduce the time required to compute and visualize high fideli ...

    SBIR Phase II 2010 Department of DefenseDefense Threat Reduction Agency
  2. Platelet-based Nanoparticle Therapy for Prostate Cancer

    SBC: ANDROBIOSYS, INC.            Topic: NCI

    The goal of this Phase II proposal is to develop directed energy transfer methods for imaging, tissue ablation and release of therapeutic modalities targeted to the vasculature of prostate cancer. The platform technology is a freeze-dried human platelet (Stasix particles) that contains super paramagnetic iron oxide (SPIO) nanoparticles. The Phase I program showed that SPIO-Stasix particles selecti ...

    SBIR Phase II 2010 Department of Health and Human Services
  3. Preclinical Studies on Polyunsaturated Fatty Acid-Taxoid Conjugate for IND Filing


    DESCRIPTION (provided by applicant): An unmet need in the area of cytotoxic therapy for human cancer is the development of an agent that is highly effective, yet is relatively safe with respect to side effects. The use of most chemotherapeutic drugs in human cancer treatment is accompanied by a variety of side effects including hair loss, corrugated and twisted nail formation and hemorrhage of th ...

    SBIR Phase II 2010 Department of Health and Human Services
  4. Ultrasonic Assessment of the Forearm

    SBC: CYBERLOGIC INC            Topic: NIA


    SBIR Phase II 2010 Department of Health and Human Services
  5. Generation of 3D root canals from two or more oral radiographs

    SBC: Imagination Software Corporation            Topic: NIDCR

    DESCRIPTION (provided by applicant): About 15 million root canals are performed each year in the United States. Failure rates are about 10%, with the failed initial treatment reflecting costs in the US of over 900 million dollars per year. While there are a number of causes of the failures, one of the primary causes is the inability to assess the difficulty of the root canal's morphology, i.e., it ...

    SBIR Phase I 2010 Department of Health and Human Services
  6. Pandemic or Mass Casualty Aseptic Shared Ventilation


    DESCRIPTION (provided by applicant): The CDC's FluSurge simulation shows that there will be a shortage of ventilators within the United States when the H5N1 flu virus mutates to airborne human-to-human transmission and the pandemic arrives. In the United States, it is estimated that nearly 85% of the 105,000 ventilators are in use at any time resulting, leaving in than 16,000 available to respond ...

    SBIR Phase II 2010 Department of Health and Human Services
  7. Approach-specific, multi-GPU, multi-tool, high-realism neurosurgery simulation

    SBC: Kitware, Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): Simulation has made limited inroads in neurosurgery, despite validation studies demonstrating its advantages over traditional training. It has emphasized needle insertion and failed to address requirements of surgeons-in-training on most future caseloads. Existing simulators exhibit brain mesh that lacks separability about fissures, is insufficiently sparse to ...

    SBIR Phase I 2010 Department of Health and Human Services
  8. Scalable computational tools for reverse engineering neural circuits from histolo

    SBC: Kitware, Inc.            Topic: NIMH

    DESCRIPTION (provided by applicant): We propose to develop the computational infrastructure necessary for future large-scale reverse engineering of cortical circuits. Neuroscience researchers are using confocal and electron micrograph (EM) techniques to scan neural tissue at high resolution. Their goal is to capture a detailed map of all neurons and synapses within the nervous system of an organi ...

    SBIR Phase I 2010 Department of Health and Human Services
  9. Validation of a Rodent Mutagenicity Assay

    SBC: Litron Laboratories Ltd            Topic: NIEHS

    DESCRIPTION (provided by applicant): Mutation to DNA is a primary mechanism by which cancers arise. These events have also been implicated in diseases such as atherosclerosis, and processes such as aging. Therefore, there is an important need for sensitive analytical methods that facilitate the study of mutagenesis, as well as the identification of chemical or physical agents that can mutate DNA. ...

    SBIR Phase I 2010 Department of Health and Human Services
  10. Rapid Radiation Dose Estimation

    SBC: Litron Laboratories Ltd            Topic: NIAID

    DESCRIPTION (provided by applicant): Human exposure to radiation, whether by accidental or intentional use, has the potential to impact large populations and severely tax the facilities and resources mandated to respond to such incidents. The current state of clinical management of radiation exposure is lacking in its ability to rapidly and reliably provide relevant human dose estimation. Such inf ...

    SBIR Phase I 2010 Department of Health and Human Services
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