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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Validation of a Cranial Neurosurgery Simulator and Assessment of Minimally Invasive Techniques

    SBC: Simulated Inanimate Models LLC            Topic: 103

    Project SummarySimulation training is unique in its ability for repetitive practice of a wide variety of scenarios and to reflect on performance without jeopardizing a patient s safetySurgical skills simulators have been successful in bridging gaps of the current training modelhoweverthese simulators fall short of offering a complete operative experienceOperative exposure with live patients still ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Molecular Biomarkers of Dangerous Intracranial Aneurysms

    SBC: NEUROVASCULAR DIAGNOSTICS, INC.            Topic: 103

    Abstract Rupture of intracranial aneurysmsIAscauses intracranial hemorrhaging that leads to high rates of neurological deficits and deathAlthough rupture rates are lowclinicians must decide whether to treat or monitor these potentially dangerous lesionsIn the current clinical practicethe most common metric to measure risk of rupture is aneurysm sizemm ormmHoweverclinical data show that small aneur ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Gene Therapy to Protect the Lung from Oxidant Stress

    SBC: LEXEO Therapeutics LLC            Topic: NHLBI

    AbstractThe focus of this proposal is the development of therapy to protect the lung with an extracellular anti oxidant defense to treat chronic obstructive pulmonary diseaseCOPDa chronic disorder in which inhaled oxidants from tobacco smokepollution and generated within the lung by activated inflammatory cells perpetuate injury to the lung epithelium and endotheliumThe LEXEO strategy is to use in ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. A Novel Approach to Restore Epithelial Barrier Homeostasis to Treat Inflammatory Bowel Disease

    SBC: THELIUM THERAPEUTICS INC.            Topic: 300

    SUMMARY Intestinal barrier function is compromised in enteric and systemic diseasesincluding infectious enterocolitisfood allergyceliac diseasegraft versus host diseaseGvHDand inflammatory bowel diseaseIBDThe co founders of Thelium Therapeutics discovered the central role of myosin light chain kinaseMLCKin barrier regulation and demonstrated that targeted intestinal epithelial MLCK inhibition limi ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Extended preservation of human livers: a nature inspired, high subzero controlled, limited freezing approach

    SBC: SYLVATICA BIOTECH INC            Topic: 300

    ABSTRACT in liver waitlist patients do not receive a new liver in time while many more patients are never listed but could benefit from liver replacement While bridge to transplant technologies ventricular assist devices and dialysis have transformed the outlook for heart failure and kidney failure no such treatment exists for patients with liver failure Current liver sharing limits approx miles a ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Optimizing membrane repair for the treatment of Duchenne muscular dystrophy

    SBC: MYOFINITY BIOSCIENCES INC            Topic: NIAMS

    PROJECT ABSTRACT The long term goal of this project is to optimize a protein therapeutic for Duchenne muscular dystrophyDMDand potentially other muscle diseasesthat will enhance the repair capacity of muscle cell membranes that are compromised by mutations in the dystrophin dystroglycan complexMutations in the dystrophin dystroglycan complex result in Duchenne muscular dystrophyMyos Incis developi ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A deep learning platform to evaluate the reliability of scientific claims by citation analysis.

    SBC: Scite, Inc.            Topic: NIDA

    The opioid epidemic in the United States has been traced to aletter reporting in the prestigious New England Journal of Medicine that synthetic opioids are not addictiveA belated citation analysis led the journal to append this letter with a warning this letter has beenheavily and uncritically citedas evidence that addiction is rare with opioid therapyThis epidemic is but one example of how unreli ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Evaluating the Usability, Efficacy and Commercial Utility of a Digital Platform to Deliver Comprehensive Treatment for Opioid Use Disorder

    SBC: Boulder Care, Inc.            Topic: NIDA

    PROJECT SUMMARY Opioid use disorderOUDis a problem of national concernMedication based treatmentMTreduces opioid useassociated risk behaviors and deathDespite evidence supporting MT with buprenorphinein more thanof US countiesmainly ruralthere are no prescribersPatients travel long distancesjoin waitlistsor go without MTOther barriers to care include lack of transportationcompeting demandsworkchil ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. BD2K product for enhancing phenotypic screens

    SBC: GENECENTRIX INC.            Topic: NIDA

    The public health problem addressed by the proposed project is the critical, long-term absence of progress in anti-addiction medication discovery and development. GeneCentrix’ “historeceptomics” technology has the potential to alter this trend by providing advanced insights during the process of anti-addiction medication discovery and development. Digital/computational advanced insights are ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Novel Home-Based and Low-Cost ECG Device for periodic evaluation of the presence of atrial fibrillation

    SBC: Global Instrumentation, LLC            Topic: 600

    Abstract Atrial fibrillation (AF) prevalence is estimated to 1% of the general population in the United States. A shocking 30% to 60% (according to studies) of patients with AF are unaware of their diagnosis (silent AF). Most AF patients will suffer from congestive heart failure or/and develop thromboembolic events leading to a dramatic reduction of patients’ quality of life, and a significant c ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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