Award Data

Summary: AlphaThera continues to scale commercialization of its site-specific antibody conjugation products and has encountered welcoming signs of consumer interest across the US and the world, with sales in several countries and continued customer inquiries. However, increasing expenses associated with scaling and commercialization have led us to explore additional sources of funds. The TABA fund ...

The special properties of quantum states make them attractive for emerging applications in quantum communication and computing. However, the very properties of quantum states that make them useful also make them difficult to measure. Quantum state tomography is a measurement tool which allows for complete characterization of quantum states. Although great progress has been made in researching quan ...

There is a growing need for the wider deployment of infrared cameras in various defense applications, from handheld to vehicle-mounted. Meeting this requires a low-cost imaging device that has low noise and high frame rates. Microbolometers largely fill this need in the longwave infrared regime, although they suffer from relatively slow response times and are near their technological performance l ...

High-speed flight vehicles commonly use carbon / carbon (C/C) and carbon / silicon carbide (C/SiC) for structural components. These materials are chosen because of their superior structural properties at elevated temperatures. Most often, their properties are characterized using flat and thin material test plates. While this approach is convenient, it is not guaranteed to yield material properties ...

Project Summary We propose a two-arm adaptive Phase II clinical trial to evaluate ONC201, a selective antagonist of the G protein-coupled receptor (GPCR) dopamine receptor domain 2 (DRD2), in recurrent glioblastoma (GBM) and diffuse midline glioma associated with very poor prognoses and limited treatment options. DRD2 is overexpressed in high grade gliomas and controls Akt/ERK signaling pathways. ...

Abstract for Supplement ApplicationThe ultimate goal for our original project was to complete the proof-of-concept work, and the multitude of pharmacodynamic, pharmacokinetic, toxicokinetic, safety, and toxicology studies required by the FDA to apply for an IND. We are fully satisfied that we have generated a new chemical entity that acts at a novel binding site on the GABA-A receptor and acts in ...

We have discovered a novel Type IIb prodrug of riluzole, trigriluzole (FC-4157, BVH-4157), which has the potential to substantially improve therapy for the treatment of the devastating condition of metastatic melanoma acting via a novel glutamatergic mechanism of action. While riluzole has shown promising efficacy in treating melanoma in patients, trigrilluzole is andgt;20X more potent than riluzo ...

ABSTRACT Front-line therapy for patients diagnosed with Hodgkin’s lymphoma or germ cell cancers includes the drug bleomycin, a highly effective agent with a debilitating side effect. About 10-12% of bleomycin-treated patients develop pneumonitis with progression to pulmonary fibrosis during therapy as a direct result of bleomycin. An estimated 10-20% of these cases are fatal. The current standar ...

A challenge for Artificial Intelligence recommenders is explaining their reasoning to users. Humans tend to explain concepts with symbolic narratives, which contrasts the way non-symbolic machine learning represents concepts. This research addresses this challenge by grounding the research in the problem of helping transitioning veterans find relevant careers. The developed prototype will provide ...

Development of a urine test for the early detection of liver cancer The need to develop an effective method for detecting liver cancer is urgent. HCC, a primary liver cancer, is the third leading cause of cancer deaths worldwide and the fastest rising cancer in US. HCC has a 5-year survival rate of less than 15%, if detected early, the survival rate can be as high as 40%. The survival rate drops s ...