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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Phase II SBIR: Responding to NDM-1- Advancement of a new MBL inhibitor to IND

    SBC: VenatoRx Pharmaceuticals, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Multi drug resistance in Enterobacteriaceae is regarded as a healthcare crisis While carbapenems are among the most prescribed antibiotics for infections caused by these organisms carbapenem resistance conferred by zinc based metallo carbapenemases Amber Class B is a growing global health concern that threatens to erode the efficacy of these antibiotics both in th ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  2. Preserving beta-lactam utility vs pathogens producing any class of beta-lactamase

    SBC: VenatoRx Pharmaceuticals, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Multi drug resistance in Enterobacteriaceae is regarded as a healthcare crisis This crisis has been further amplified by the recent emergence of the NDM andquot super bug geneandquot a zinc based metallo lactamase Amber Class B in Enterobacteriaceae Members of this family of resistance enzymes are found on promiscuous plasmids with other MDR resistance mechanisms ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a Urine Test for the Early Detection of Liver Cancer

    SBC: JBS Science, Inc            Topic: NCI

    DESCRIPTION provided by applicant Development of a urine test for the early detection of liver cancer The need to develop an effective method of detecting hepatocellular carcinoma HCC is urgent HCC is the third leading cause of cancer deaths and has a year survival rate of less than If HCC is identified early the survival rate can be as high as The survival rate drops significantly however to as l ...

    SBIR Phase II 2013 Department of Health and Human Services
  4. In-Patient Pediatric Gastrojejunal Tube Cleaner Eliminating Surgical Intervention

    SBC: ACTUATED MEDICAL, INC.            Topic: NICHD

    DESCRIPTION provided by applicant In this Phase II NIH SBIR Actuated Medical Inc will complete the development of the Pedi GJ ClearTM device for clearing occlusions and restoring patency in situ to pediatric gastrojejunal feeding tubes GJ tubes eliminating the need to surgically replace clogged tubes Public Health Problem Enteral nutrition is provided for patients that have a functioning lower gas ...

    SBIR Phase II 2013 Department of Health and Human Services
  5. Novel schemes for highly reliable aerospace electromechanical primary actuation systems

    SBC: LCDRIVES CORP.            Topic: SB132005

    There is a need to achieve 10^-9 reliability for actuators for critical aerospace applications and this precludes single point failure for all but the simplest and most reliable electrical and mechanical components. LC Drives proposes a method of constructing a high reliability linear actuator for critical aerospace applications that is designed such that jams caused by conventional electrical a ...

    SBIR Phase I 2013 Department of DefenseDefense Advanced Research Projects Agency
  6. Novel Extensible Design Approaches for Advanced Aircraft Composite Structural Architectures (MSC P4135)

    SBC: Materials Sciences LLC            Topic: ST13A006

    Among the factors that inhibit the use of composite materials in both general aviation aircraft and DoD platforms are the high cost of engineering and the cost of certification. Unless manufacturers can control risk when introducing new materials and pro

    STTR Phase I 2013 Department of DefenseDefense Advanced Research Projects Agency
  7. Looking Glass

    SBC: Intific, Inc.            Topic: 004

    Looking Glass is an immersive, story-driven game experience that enables computer science education for students K-12. It presents learning in a game-based series of challenge levels that permit a high degree of player choice in tailoring educational progression and adapting game systems that present both STEM and SEL interactions. Gameplay occurs within a futuristic Wonderland, where proficiency ...

    SBIR Phase I 2013 Department of DefenseDefense Advanced Research Projects Agency
  8. Improved Dried Biological Specimen Materials, Recovery and Processing for Diagnostics

    SBC: Connecticut Analytical Corporation            Topic: SB112005

    The dried blood spot (DBS) method is an alternative to venipuncture. The available data indicates that the DBS method is both precise and accurate for a diverse range of compounds. We discovered that proprietary additives vastly improve extraction of proteins in DBS using electrospray. Our unexpected results appear to dramatically increase analyte recovery concentration while reducing DBS prep, an ...

    SBIR Phase II 2013 Department of DefenseDefense Advanced Research Projects Agency
  9. Continuing Care Retirement Community Experience

    SBC: Actuarial Forecasting And            Topic: N/A

    N/A

    SBIR Phase I 1994 Department of Health and Human Services
  10. Somatic Cell Gene Therapy for Hemophilia B

    SBC: Alexion Pharmaceuticals, Inc.            Topic: N/A

    Blood coagulation factor IX is absent or deficient in hemophilia B patients. Current therapy, thetransfusion of human whole blood components, is effective, but it is not prophylactic or free of risk.Our long term objective is the development of a somatic cell gene therapy for hemophilia B. Autologouscapillary endothelial cells from adipose tissue of a hemophilia B patient will be isolated, transdu ...

    SBIR Phase I 1994 Department of Health and Human Services

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