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DESCRIPTION (provided by applicant): While density-functional calculations of the energy are now feasible for biomolecules, the use of density-functional geometry optimizers is still confined to relatively small molecules containing no more than thirty atoms. The key limitation of conventional density-functional geometry optimizers is that the cost of the geometry optimization scales at least qua ...

THERE IS SUBSTANTIAL NEED FOR NEW SENSORS WHICH MEASURE ABSOLUTE DISTANCE FOR APPLICATIONS IN ROBOTIC POSITIONING, MACHINE VISION, AUTOMATIC INSPECTION AND GAUGING. WITH ITS ABILITY TO MEASURE NON-CONTINUOUS CHANGES IN POSITION, THE SENSOR COULD PROVIDE FEEDBACK MEASUREMENTS FOR CLOSED LOOP POSITION CONTROL FOR ROBOTS, CMMS AND MACHINE TOOLS. FOR AUTOMATIC INSPECTION, A HIGHLY ACCURATE DISTANCE ME ...

Although global pose is essential for success in certain vehicle missions and tasks, when GPS is denied there is no single technology (source) that can robustly estimate global pose without suffering from one or more failure modes. We propose to design an architecture that provides robustness by integrating automated celestial navigation, registering on-board sensor data to a map (map registration ...

DESCRIPTION (provided by applicant): The widespread adoption of picture archiving and communications systems (PACS) in radiology and the implementation and deployment of the DICOM communication standard represent an opportunity to link multiple PACS at multiple sites into a distributed data warehouse of great potential utility for investigators in oncology research and epidemiology. Where the f ...

DESCRIPTION (provided by applicant): Ion channels function as signaling intermediaries that are involved in nerve signal propagation, muscle contraction, cardiopulmonary regulation, and cell metabolism. Their importance is underscored by the existence of dozens of ion channel-specific drugs that treat important neurological and cardiovascular diseases. Despite their importance in human health, ion ...

THE GOAL OF THIS RESEARCH IS TO DEVELOP A PROCESSOR WHICH USES TIME-FREQUENCY TRANSFORMS TO EXTRACT THE INSTANTANEOUS FREQUENCY OF A SIGNAL IN REAL TIME. IN THE PROCESSOR, THE SIGNAL WILL BE SPLIT INTO TWO PATHS. IN ONE PATH THE SIGNAL WILL BE DIRECTED TO A DELAY LINE AND THEN TO PROGRAMMABLE FILTERS. IN THE OTHER PATH, THE SIGNAL WILL BE DIRECTED TO OUR TIME-FREQUENCY DETECTOR WHICH WILL MEASURE ...

The increase in extreme weather events over the past several decades has underscored the need for regional planning strategies that will support future preparedness and mitigate climate change impact on local communities across the United States. While existing climate modeling tools for non-researchers support a conceptual understanding of climate change at the global level, they do not address t ...

The Acoustically Synchronized Store Ejection/Release Technology (ASSERT) test process was developed by CRAFT Tech. This research has produced a capability to conduct small scale dynamic drop tests instrumented with stereo-photogrammetry to track store motion and synchronize this with unsteady weapons bay flowfield measurements. An advanced pneumatic ejection system has been developed which support ...

THE NATURAL FREQUENCY OF A MECHANICAL SYSTEM PROVIDES INSIGHT INTO ITS CONDITION. THE DEGREE OF STRESS TO WHICH A SYSTEM IS SUBJECTED IS REFLECTED IN SOUNDS PRODUCED BY THE SYSTEM WHEN EXCITED. IN PARTICULAR, THE MOVEMENT OF A MECHANICAL OR BIOLOGICAL CARDIAC VALVE PROSTHESIS GENERATES AUDIBLE SOUND; THE NATURAL FREQUENCY OF A CORRECTLY FUNCTIONING VALVE DIFFERS FROM THAT OF A FAULTY VALVE. THIS R ...

DESCRIPTION provided by applicant In this NIH SBIR Phase II Actuated Medical Inc will finalize and clinically test the andquot Active Fine Gauge Spinal Needle with CSF Sensing to Minimize PDPH and Dura Damage andquot Phase I achieved all Specific Aims and demonstrated that the Smooth Insertion Spinal SIS System provided greater control for the clinician by reducing the buckling of G tra ...