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Adjunctive antithrombotic treatment with dual antiplatelet therapyaspirinP Yantagonistplus anticoagulantheparin or bivalirudinis a guideline mandated for percutaneous coronaryinterventionPCIpatientsDespite aggressive antithrombotic therapyhowevermyocardialperfusion after PCI remains inadequate in many patientsReocclusion from recurrent thrombosiscontinues to occurand dose limiting bleeding occurs ...

DESCRIPTION provided by applicant Hospital acquired microbial infections are the fourth largest killer in America taking lives and adding $ B to hospital costs The emergence of drug resistant microbes has further amplified public health concern Fungi are prolific producers of anti microbial secondary metabolites SM and since the turn of the century have provided of bioactive m ...

PROJECT SUMMARY There is need for an artificial oxygenOcarrier to substitute for banked blood in settings wherestored blood is unavailablepre hospital care transportaustere environmentsundeveloped countriesorundesirabletransfusion risk exceeds benefitTo address this needwe developedErythroMerEMa first inclass nano cyte blood substituteEM is a deformablecross linked polymeric nanoparticle that inco ...

A system to covertly communicate in underwater acoustic shallow water environment for Naval applications is described. Techniques for clandescent and directional communication are evaluated. Broadband underwater communications are developed.

Despite the myriad major advances in cardiologythe prognosis for patients with severemedically refractive heart failureHFis exceedingly poorApproximatelydeaths occur annually in patients with HF who have endured an impaired quality of life often accompanied by significant economic and personal losses due to recurrent hospitalizationsAt leastof these deaths were directly related to severe heart fai ...

PROJECT SUMMARY The economic and social burden for the treatment of chronic and infectious diseases is enormousandgt $BThe emergence of drug resistant microbesthe diminishing supply of novel classes of antibioticsand the dramatic reduction in discovery and development of anti infectiveanti proliferation and anti inflammation agents have further amplified public health concernFungi are prolific pro ...

Electrical systems are being designed with ever increasing power densities, particularly future radar and electronic warfare systems built with Gallium Nitride on Silicon Carbide Monolithic Integrated Circuits (GaN MMICs). Today’s GaN MMICs use solid metal, low-coefficient of thermal expansion heat spreaders (e.g., Copper-Tungsten). But solid-state heat spreaders cannot meet the size, weight, po ...

Aircraft designed for today’s Navy are being pressed into service beyond their design life resulting in increase in failure rates of parts that were not expected to fail. The Phase II base project will be based on Phase I and Phase I Option work to develop a full restoration system that can be used to restore various aircraft components. The components in a damaged aircraft component will be use ...

Seam failures of flexible inflatable hulls is the primary reason for failures of military RHIBS and CRCs.These failures are a result of the current manufacturing methods being used, and which have been in place for over fifty years.Whats more, the manufacturing methods and fragmented supply chain of these hulls result in very long and unreliable lead times.These shortcomings impact the survivabili ...